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Başlık: Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo
Yazarlar: Uludağ Üniversitesi/Mühendislik Fakültesi/Tekstil Mühendisliği Bölümü.
Uludağ Üniversitesi/Tıp Fakültesi/Plastik ve Rekonstrüktif Cerrahi Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.
0000-0003-1777-3977
0000-0002-9156-2214
Coşkun, Gökçe
Karaca, Esra
Özyurtlu, Mustafa
Özbek, Serhat
Yermezler, Aysun
Çavuşoğlu, İlkin
AAS-8480-2020
AFT-8971-2022
AAH-5441-2021
56094840400
17344029200
39962152600
7005245657
55938747300
6602910240
Anahtar kelimeler: Electrospinning
Nanofiber
Alginate
Wound dressing
Histological evaluation
In vivo
Normal human keratinocytes
Nanofibrous membrane
Sodium alginate
Fibers
Engineering
Materials science
Artificial organs
Biomaterials
Polyvinyl alcohols
Tissue
Conventional methods
Electrospinning method
Histological evaluation
In-vivo
Post-operative days
Process parameters
Wound dressing materials
Wound dressings
Nanofibers
Yayın Tarihi: 2014
Yayıncı: Ios Press
Atıf: Coşkun, G. vd. (2014). "Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo". Bio-Medical Materials and Engineering, 24(2), 1527-1536.
Özet: Poly(vinyl alcohol)/sodium alginate nanofibrous mats were produced by electrospinning method at optimum process parameters. Evaluation of alginate-based electrospun nanofibrous mats as a wound dressing material and their comparison to commercially available wound dressings produced with conventional methods were carried out in vivo. Tissue specimens were examined histopathologically on 4th, 6th, 15th, 21st postoperative days. In contrast to other dressings it was observed that nanofibrous mat could survive on the wound crust in early stages of healing. In terms of epithelization, epidermis characteristics, vascularization and formation of hair follicles, nanofibrous mat showed the best healing performance. This could be explained with presence of nanofibrous mat acting as an artificial skin on the wound region until new tissue regenerated.
URI: https://doi.org/10.3233/BME-130956
http://hdl.handle.net/11452/28642
ISSN: 0959-2989
1878-3619
Koleksiyonlarda Görünür:Scopus
Web of Science

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