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Başlık: Esmolot pretreatment reduces the frequency and severity of pain on injection of rocuronium
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı.
Yavaşçaoğlu, Belgin
Kaya, Fatma Nur
Özcan, Berin
AAG-9356-2021
AAI-7914-2021
AAI-8213-2021
6602742300
7003619647
6603825848
Anahtar kelimeler: Esmolol
Injection pain
Lidocaine
Rocuronium
Spomtaneous movements
Lidocaine
Prevention
Vecuronium
Anesthesia
Propofol
Blockade
Fentanyl
Bromide
Anesthesiology
Yayın Tarihi: Eyl-2007
Yayıncı: Elsevier Science
Atıf: Yavaşçaoğlu, B. vd. (2007). "Esmolot pretreatment reduces the frequency and severity of pain on injection of rocuronium". Journal of Clinical Anesthesia, 19(6), 413-417.
Özet: Objective: To determine the effect of esmolol on the frequency and severity of pain and withdrawal reactions after injection of rocuronium and to compare it with lidocaine and placebo. Design: Prospective, randomized, double-blind, placebo-controlled study. Setting: Single university hospital. Patients: 120 ASA physical status I and 11 patients undergoing general anesthesia for elective surgery. Interventions: Patients were randomized to receive esmolol (0.5 mg/kg), lidocaine (0.5 mg/kg), or placebo, followed by a subparalyzing dose of rocuronium. After induction of anesthesia with propofol and fentanyl, an intubating dose of rocuronium 0.6 mg/kg was given. Measurements: Patients were observed after injection of rocuronium 0.05 mg/kg, then immediately asked if they had pain in the arm. The response was assessed; discomfort, pain, and withdrawal of the hand were recorded and graded using a 4-point scale (none, mild, moderate, or severe). After the intubating dose of rocuronium, withdrawal reactions were scored as follows: (a) no pain response, (b) pain limited to the wrist, (c) pain limited to the elbow/shoulder, or (d) generalized pain response. Results: 31 patients (77.5%) in the esmolol group, 32 (80%) in the lidocaine group, and 15 (37.5%) in the placebo group reported no pain (both groups vs placebo, P < 0.001). Moderate pain was seen in only one patient receiving lidocaine, in 6 placebo patients, but in none in the esmolol group (esmolol vs placebo, P < 0.05). Severe pain was felt by 8 patients receiving placebo, but by none receiving esmolol or lidocaine (P < 0.01). Frequency of withdrawal response after rocuronium was 2.5%, 17.5%, and 40% in the esmolol, lidocaine, and placebo groups, respectively (esmolol group vs placebo, P < 0.001; lidocame group vs placebo, P < 0.05). Conclusion: Esmolol, like lidocame, reduces the frequency of pain and withdrawal reaction associated with rocuronium injection.
URI: https://doi.org/10.1016/j.jclinane.2007.02.011
https://www.sciencedirect.com/science/article/pii/S0952818007001729
http://hdl.handle.net/11452/28765
ISSN: 0952-8180
1873-4529
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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