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Başlık: Activation of orexin neurons through non-NMDA glutamate receptors evidenced by c-Fos immunohistochemistry
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.
0000-0001-5757-8450
0000-0003-3463-7483
Eyigör, Özhan
Minbay, Zehra
Çavuşoğlu, İlkin
ABE-5128-2020
ABC-1475-2020
6603109907
8220935200
56009155800
Anahtar kelimeler: Prepro-orexin
Kainic acid
CNQX
Kainate
AMPA
Hypothalamus
Regulate feeding-behavior
Hypocretin orexin
Sleep
Neuroendocrine
Subunit
Systems
Expression
Peptides
Endocrinology & metabolism
Yayın Tarihi: Şub-2010
Yayıncı: Humana Press
Atıf: Eyigör, Ö. vd. (2010). "Activation of orexin neurons through non-NMDA glutamate receptors evidenced by c-Fos immunohistochemistry". Endocrine, 37(1), 167-172.
Özet: Orexin neuropeptides participate in the regulation of feeding as well as the regulation and maintenance of wakefulness and the cognitive functions. Orexin A and B share a common precursor, prepro-orexin and neurons are localized in the lateral hypothalamus. Physiological studies showed that these neurons are regulated by glutamatergic innervations. We aimed to assess the effects of kainic acid as a potent agonist for non-NMDA glutamate receptors in the activation of orexin neurons. We also analyzed the effect of glutamate antagonist CNQX, injected prior to kainic acid, on this activation. Expression of c-Fos protein was used as a marker for neuronal activation. Dual immunohistochemical labeling was performed for prepro-orexin and c-Fos and the percentages of c-Fos-expressing orexin neurons were obtained for control, kainic acid, and CNQX groups. Kainic acid injection caused statistically significant increase in the number of c-Fos-positive neurons when compared to control group (62.69 and 36.31%, respectively). Activation of orexin neurons was blocked, in part, by CNQX (43.36%). In the light of these results, it is concluded that glutamate takes part in the regulation of orexin neurons and partially exerts its effects through non-NMDA glutamate receptors and that orexin neurons express functional non-NMDA receptors.
URI: https://doi.org/10.1007/s12020-009-9284-x
https://link.springer.com/article/10.1007/s12020-009-9284-x
http://hdl.handle.net/11452/28809
ISSN: 0969-711X
Koleksiyonlarda Görünür:Scopus
Web of Science

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