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Başlık: Thyroid stimulating hormone levels rise after assisted reproductive technology
Yazarlar: Reinblatt, Shauna Leigh
Herrero, Belen
Correa, José Andrés
Shalom-Paz, Einat
Wiser, Amir
Morris, David V.
Holzer, Hananel E.G.
Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.
0000-0003-1106-3747
Ata, Barış
16306205100
Anahtar kelimeler: Genetics & heredity
Obstetrics & gynecology
Reproductive biology
Thyroid function
Estradiol
Ovarian hyperstimulation
Assisted reproductive technology
Thyroid stimulating hormone
Antithyroid antibodies
Euthyroid women
Pregnancy
Hypothyroidism
Levothyroxine
Autoimmunity
Dysfunction
Thyroxine
History
Disease
Yayın Tarihi: Eki-2013
Yayıncı: Springer/Plenum Publishers
Atıf: Reinblatt, S. vd. (2013). "Thyroid stimulating hormone levels rise after assisted reproductive technology". Journal of Assisted Reproduction and Genetics, 30(10), 1347-1352.
Özet: The goal of this study was to determine whether high E2 levels after controlled ovarian hyperstimulation affect TSH. Patients completing ART cycles between April-October 2010 were eligible for this cohort study. 180 patients were recruited however those with known thyroid disease were excluded. The final analysis included 154 subjects. Blood was collected at each visit during the ART cycle as well as at the pregnancy test. Samples were frozen at -20 A degrees C and analyzed together for E2 and TSH using the same assay kit once all patients had completed their cycles. All participants were treated at the McGill University Health Center. A paired t-test was used to study the difference in TSH levels recorded at maximal and minimal Estradiol levels during ovarian stimulation. Multiple regression analysis was then used to determine if factors such as anti-thyroid antibodies and ovarian reserve measures affect this change in TSH. We used multiple imputation methods to account for missing data. As E2 levels rose from low to supra-physiologic levels during treatment, TSH levels also rose significantly. This increase was clinically significant by the time of pregnancy test. The factors that potentially affected the change in TSH were: male factor/tubal factor infertility, type of protocol used as well as the presence of thyroid antibodies. Although TSH increases during ART, this change only becomes clinically significant on the day of pregnancy test. Future studies should examine TSH changes specifically in certain "at-risk" sub-groups such as those with antibodies and known thyroid disease.
URI: https://doi.org/10.1007/s10815-013-0081-3
https://pubmed.ncbi.nlm.nih.gov/23955685/
http://hdl.handle.net/11452/28866
ISSN: 1058-0468
1573-7330
Koleksiyonlarda Görünür:Scopus
Web of Science

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