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Başlık: Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.
0000-0002-2593-7196
0000-0002-9562-4195
Garip, Gökhan
Sarandöl, Emre
Kaya, Ekrem
ABE-1716-2020
AAG-7319-2021
40261542500
55943324800
7004568109
Anahtar kelimeler: Gastroenterology & hepatology
Acute pancreatitis
Exocrine dysfunction
Endocrine dysfunction
Pancreas function test
Pancreatic necrosis
Acute biliary pancreatitis
Necrotizing pancreatitis
Recovery
Necrosectomy
Yayın Tarihi: 28-Kas-2013
Yayıncı: Baishideng Publishing Group
Atıf: Garip, G. vd. (2013). "Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis". World Journal of Gastroenterology, 19(44), 8065-8070.
Özet: AIM: To evaluate the effects of disease severity and necrosis on organ dysfunctions in acute pancreatitis (AP). METHODS: One hundred and nine patients treated as AP between March 2003 and September 2007 with at least 6 mo follow-up were included. Patients were classified according to severity of the disease, necrosis ratio and localization. Subjective clinical evaluation and fecal pancreatic elastase-I (FPE-I) were used for exocrine dysfunction evaluation, and oral glucose tolerance test was completed for endocrine dysfunction. The correlation of disease severity, necrosis ratio and localization with exocrine and endocrine dysfunction were investigated. RESULTS: There were 58 male and 51 female patients, and mean age was 56.5 +/- 15.7. Of the patients, 35.8% had severe AP (SAP) and 27.5% had pancreatic necrosis. Exocrine dysfunction was identified in 13.7% of the patients [17.9% were in SAP, 11.4% were in mild AP (MAP)] and 34.7% of all of the patients had endocrine dysfunction (56.4% in SAP and 23.2% in MAP). In patients with SAP and necrotizing AP (NAP), FPE-I levels were lower than the others (P < 0.05 and 0.001 respectively) and in patients having pancreatic head necrosis or near total necrosis, FPE-1 levels were lower than 200 mu g/g stool. Forty percent of the patients who had undergone necrosectomy developed exocrine dysfunction. Endocrine dysfunction was more significant in patients with SAP and NAP (P < 0.001). All of the patients in the necrosectomy group had endocrine dysfunction. CONCLUSION: Patients with SAP, NAP, pancreatic head necrosis and necrosectomy should be followed for pancreatic functions.
URI: https://doi.org/10.3748/wjg.v19.i44.8065
https://www.wjgnet.com/1007-9327/full/v19/i44/8065.htm
http://hdl.handle.net/11452/28931
ISSN: 1007-9327
2219-2840
Koleksiyonlarda Görünür:Scopus
Web of Science

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