Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/28959
Title: Use of diffusion weighted imaging in differentiating between maligant and benign meningiomas. A multicenter analysis
Authors: Surov, Alexey
Ginat, Daniel T.
Şanverdi, Eser
Lim, C. C. Tchoyoson
Yogi, Akira
Cabada, Teresa
Wienke, Andreas
Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.
0000-0002-3425-0740
Hakyemez, Bahattin
AAI-2318-2021
6602527239
Keywords: Neurosciences & neurology
Surgery
DWI
Meningioma
MRI
Grade
Subtypes
ADC
Issue Date: Apr-2016
Publisher: Elsevier Science
Citation: Surov, A. vd. (2016). "Use of diffusion weighted imaging in differentiating between maligant and benign meningiomas. A multicenter analysis". World Neurosurgery, 88, 598-602.
Abstract: BACKGROUND: Meningioma is the most frequent intracranial tumor and is often an incidental finding on imaging. Some imaging-based scores were suggested for differentiating low- and high-grade meningiomas. The purpose of this work was to compare diffusion-weighted imaging findings of different meningiomas in a large multicenter study by using apparent diffusion coefficient (ADC) values for predicting tumor grade and proliferation potential. METHODS: Data from 7 radiologic departments were acquired retrospectively. Overall, 389 patients were collected. All meningiomas were investigated by magnetic resonance imaging (1.5-T scanner) by using diffusion-weighted imaging (b values of 0 and 1000 s/mm(2)). The comparison of ADC values was performed by Mann-Whitney U test. RESULTS: World Health Organization grade I was diagnosed in 271 cases (69.7%), grade II in 103 (26.5%), and grade III in 15 patients (3.9%). Grade I meningiomas showed statistically significant higher ADC values (1.05 +/- 0.39 x 10(-3) mm(2)s(-1)) in comparison with grade II (0.77 +/- 0.15 x 10(-3) mm(2)s(-1); P = 0.001) and grade III tumors (0.79 +/- 0.21 x 10(-3) mm(2)s(-1); P = 0.01). An ADC value of <0.85 x 10(-3) mm(2)s(-1) was determined as the threshold in differentiating between grade I and grade II/III meningiomas (sensitivity, 72.9%; specificity, 73.1%; accuracy, 73.0%). Ki67 was associated with ADC (r = -0.63, P < 0.001). The optimal threshold for the ADC was (less than) 0.85 x 10(-3) mm(2)s(-1) for detecting tumors with high proliferation potential (Ki67 >= 5%). CONCLUSIONS: The estimated threshold ADC value of 0.85 can differentiate grade I meningioma from grade II and III tumors. The same ADC value is helpful for detecting tumors with high proliferation potential.
URI: https://doi.org/10.1016/j.wneu.2015.10.049
https://www.sciencedirect.com/science/article/pii/S1878875015013935
http://hdl.handle.net/11452/28959
ISSN: 1878-8750
1878-8769
Appears in Collections:PubMed
Scopus
Web of Science

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.