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Başlık: The effects of caspofungin and voriconazole in experimental Candida endophthalmitis
Yazarlar: Kuşbeci, Tuncay
Çetinkaya, Zafer
Öztürk, Faruk
Yavaş, Güliz
Ermiş, Sıtkı Samet
İnan, Ümit Ubeyt
Uludağ Üniversitesi/Tıp Fakültesi/Embriyoloji ve Histoloji Anabilim Dalı.
Avcı, Berrin
ABE-6685-2020
6603017388
Anahtar kelimeler: Caspofungin
Amphotericin-B
Endophthalmitis
Experimental
Fungal
Voriconazole
Mycotic endophthalmitis
Intravitreal injection
Fluconazole
Toxicity
Penetration
Efficacy
Fungemia
1st
Ophthalmology
Yayın Tarihi: 27-Oca-2006
Yayıncı: Taylor & Francis
Atıf: Kuşbeci, T. vd. (2007). "The effects of caspofungin and voriconazole in experimental candida endophthalmitis". Current Eye Research, 32(1), 57-64.
Özet: Purpose: To evaluate the efficacy of newly developed antifungal agents caspofungin and voriconazole in Candida albicans endophthalmitis in rabbit eyes. Methods: Thirty New Zealand white rabbits were divided into four treatment groups and one control group. One eye of each rabbit was infected by inoculation of 1 x 10(4) CFU/ml of C. albicans. Seventy-two hours after the inoculation, caspofungin 100 mu g/0.1 ml in group 1 (n = 6), voriconazole 50 mu g/0.1 ml in group 2 (n = 6), amphotencin B 10 mu g/0.1 ml in group 3 (n = 6), itraconazole 10 mu g/0.1 ml in group 4 (n = 6), and 0.1 ml NaCl 0.9% in control group (n = 6) were injected into the vitreous cavity. Clinical and histopathologic examination scores and microbiological analysis of vitreous aspirates were compared. Results: There was statistically significant difference in the clinical scores, histopathologic scores, and mean CFU/ml between the treatment and control groups (p < 0.05). In caspofungin and voriconazole groups, histopathologic scores and mean CFU were lower than other treatment groups and control group. Conclusions: Intravitreal injection of caspofungin and voriconazole was effective against C. albicans endophthalmitis in this experimental rabbit model.
URI: https://doi.org/10.1080/02713680601107157
https://www.tandfonline.com/doi/full/10.1080/02713680601107157
http://hdl.handle.net/11452/28978
ISSN: 1460-2202
0271-3683
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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