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Başlık: In vitro phannacodynaniics of enrofloxacin against an Escherichia coli gyrA mutant
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji ve Toksikoloji Anabilim Dalı.
Cengiz, Murat
Sorucu, Ali
Arslan, Erdem
ABE-5935-2020
16635026700
55236738400
55236493200
Anahtar kelimeler: Veterinary sciences
Pharmacodynamic of enrofloxacin
Escherichia coli
C-T mutation
Significant
Microdilution
Turkey
Colony-variant phenotype
Fluoroquinolone resistance
Staphylococcus-aureus
Streptococcus-pneumoniae
Quinolone resistance
Mechanisms
Mutations
Selection
Animals
Model
Yayın Tarihi: 2011
Yayıncı: Medwell Online
Atıf: Cengiz, M. vd. (2011). "In vitro phannacodynaniics of enrofloxacin against an Escherichia coli gyrA mutant". Journal of Animal and Veterinary Advances, 10(18), 2384-2388.
Özet: The aim of this study was to investigate in vitro the pharmacodynamics of Enrofloxacin (ENR) against an Escherichia coli gyrA mutant (E. coli MT/128). Broth microdilution testing was used to determine the Minimum Inhibitory Concentration (MIC) and multi-step resistance selection was performed until reaching 1 mu g ML(-1) MIC. For time-kill experiments, colony counts were determined by plating each diluted sample onto Plate Count Agar and an integrated pharmacokinetic/pharmacodynamics area measure (log ratio area) was applied to all cfu data. A single C-T mutation was found in gyrA at codon 83. Concentration-dependent bacterial killing was observed for E. coli MT/128. Bactericidal activity for this strain was achieved within 4 h at concentrations >= 8 times the MIC with no significant regrowth by 24 h.
URI: https://doi.org/10.3923/javaa.2011.2384.2388
https://medwelljournals.com/abstract/?doi=javaa.2011.2384.2388
http://hdl.handle.net/11452/29030
ISSN: 1680-5593
Koleksiyonlarda Görünür:Scopus
Web of Science

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