Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29044
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dc.contributor.authorCogliati, Massinio-
dc.contributor.authorZani, Alberto-
dc.contributor.authorRickerts, Volker-
dc.contributor.authorMcCormick, Ilka-
dc.contributor.authorDesnos-Ollivier, Marie-
dc.contributor.authorVelegraki, Aristea-
dc.contributor.authorEscandon, Patricia-
dc.contributor.authorIchikawa, Tomoe-
dc.contributor.authorIkeda, Reiko-
dc.contributor.authorBienvenu, Anne-Lise-
dc.contributor.authorTintelnot, Kathrin-
dc.contributor.authorLockhart, Shawn-
dc.contributor.authorTortorano, Anna Maria-
dc.contributor.authorVarma, Ashok-
dc.date.accessioned2022-10-11T07:32:22Z-
dc.date.available2022-10-11T07:32:22Z-
dc.date.issued2016-02-
dc.identifier.citationCogliati, M. vd. (2016). "Multilocus sequence typing analysis reveals that Cryptococcus neoformans var. neoformans is a recombinant population". Fungal Genetics and Biology, 87, 22-29.en_US
dc.identifier.issn1087-1845-
dc.identifier.issn1096-0937-
dc.identifier.urihttps://doi.org/10.1016/j.fgb.2016.01.003-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1087184516300020-
dc.identifier.urihttp://hdl.handle.net/11452/29044-
dc.description.abstractCryptococcus neoformans var. neoformans (serotype D) represents about 30% of the clinical isolates in Europe and is present less frequently in the other continents. It is the prevalent etiological agent in primary cutaneous cryptococcosis as well as in cryptococcal skin lesions of disseminated cryptococcosis. Very little is known about the genotypic diversity of this Cryptococcus subtype. The aim of this study was to investigate the genotypic diversity among a set of clinical and environmental C. neoformans var. neoformans isolates and to evaluate the relationship between genotypes, geographical origin and clinical manifestations. A total of 83 globally collected C neoformans var. neoformans isolates from Italy, Germany, France, Belgium, Denmark, Greece, Turkey, Thailand, Japan, Colombia, and the USA, recovered from different sources (primary and secondary cutaneous cryptococcosis, disseminated cryptococcosis, the environment, and animals), were included in the study. All isolates were confirmed to belong to genotype VNIV by molecular typing and they were further investigated by MLST analysis. Maximum likelihood phylogenetic as well as network analysis strongly suggested the existence of a recombinant rather than a clonal population structure. Geographical origin and source of isolation were not correlated with a specific MLST genotype. The comparison with a set of outgroup C neoformans var. grubii isolates provided clear evidence that the two varieties have different population structures.en_US
dc.description.sponsorshipUnited States Department of Health & Human Services - Z99 AI999999 - P41 RR001646en_US
dc.description.sponsorshipNational Institutes of Health (NIH) - USAen_US
dc.description.sponsorshipNIH National Center for Research Resources (NCRR)en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAtıf Gayri Ticari Türetilemez 4.0 Uluslararasıtr_TR
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGenetics & heredityen_US
dc.subjectMycologyen_US
dc.subjectCryptococcusen_US
dc.subjectC. neoformans var. neoformansen_US
dc.subjectC neoformans var. grubiien_US
dc.subjectMLSTen_US
dc.subjectRecombinationen_US
dc.subjectMolecular epidemiologyen_US
dc.subjectSpecies complexen_US
dc.subjectMating-typeen_US
dc.subjectGattiien_US
dc.subjectSerotypesen_US
dc.subjectGenotypeen_US
dc.subject.meshAmericasen_US
dc.subject.meshAsiaen_US
dc.subject.meshCryptococcosisen_US
dc.subject.meshCryptococcus neoformansen_US
dc.subject.meshEuropeen_US
dc.subject.meshGenetic variationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshMultilocus sequence typingen_US
dc.subject.meshMycological typing techniquesen_US
dc.subject.meshPhylogeographyen_US
dc.subject.meshRecombination, geneticen_US
dc.titleMultilocus sequence typing analysis reveals that Cryptococcus neoformans var. neoformans is a recombinant populationen_US
dc.typeArticleen_US
dc.identifier.wos000369778700003tr_TR
dc.identifier.scopus2-s2.0-84961616834tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.orcid0000-0002-4759-9634tr_TR
dc.identifier.startpage22tr_TR
dc.identifier.endpage29tr_TR
dc.identifier.volume87tr_TR
dc.relation.journalFungal Genetics and Biologyen_US
dc.contributor.buuauthorTöre, Okan-
dc.contributor.buuauthorAkçağlar, Sevim-
dc.relation.collaborationYurt dışıtr_TR
dc.relation.collaborationSanayitr_TR
dc.identifier.pubmed26768709tr_TR
dc.subject.wosGenetics & heredityen_US
dc.subject.wosMycologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ2en_US
dc.contributor.scopusid6505909596tr_TR
dc.contributor.scopusid6506194958tr_TR
dc.subject.scopusCryptococcus Gattii; Flucytosine; Cryptococcus Neoformansen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBelgiumen_US
dc.subject.emtreeColombiaen_US
dc.subject.emtreeCorrelation analysisen_US
dc.subject.emtreeCryptococcus neoformansen_US
dc.subject.emtreeCutaneous cryptococcosisen_US
dc.subject.emtreeDenmarken_US
dc.subject.emtreeFranceen_US
dc.subject.emtreeFungus isolationen_US
dc.subject.emtreeGene linkage disequilibriumen_US
dc.subject.emtreeGenetic recombinationen_US
dc.subject.emtreeGenetic variabilityen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeGeographic originen_US
dc.subject.emtreeGermanyen_US
dc.subject.emtreeGreeceen_US
dc.subject.emtreeItalyen_US
dc.subject.emtreeJapanen_US
dc.subject.emtreeMolecular typingen_US
dc.subject.emtreeMultilocus sequence typingen_US
dc.subject.emtreeNonhumanen_US
dc.subject.emtreePhylogenyen_US
dc.subject.emtreePopulation structureen_US
dc.subject.emtreePriority journalen_US
dc.subject.emtreeThailanden_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeUnited Statesen_US
dc.subject.emtreeVarietasen_US
dc.subject.emtreeAsiaen_US
dc.subject.emtreeClassificationen_US
dc.subject.emtreeCryptococcosisen_US
dc.subject.emtreeCryptococcus neoformansen_US
dc.subject.emtreeEuropeen_US
dc.subject.emtreeGenetic variationen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeGenotypeen_US
dc.subject.emtreeIsolation and purificationen_US
dc.subject.emtreeMicrobiological examinationen_US
dc.subject.emtreeMicrobiologyen_US
dc.subject.emtreePhylogeographyen_US
dc.subject.emtreeWestern hemisphereen_US
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