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Başlık: Multilocus sequence typing analysis reveals that Cryptococcus neoformans var. neoformans is a recombinant population
Yazarlar: Cogliati, Massinio
Zani, Alberto
Rickerts, Volker
McCormick, Ilka
Desnos-Ollivier, Marie
Velegraki, Aristea
Escandon, Patricia
Ichikawa, Tomoe
Ikeda, Reiko
Bienvenu, Anne-Lise
Tintelnot, Kathrin
Lockhart, Shawn
Tortorano, Anna Maria
Varma, Ashok
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.
0000-0002-4759-9634
Töre, Okan
Akçağlar, Sevim
6505909596
6506194958
Anahtar kelimeler: Genetics & heredity
Mycology
Cryptococcus
C. neoformans var. neoformans
C neoformans var. grubii
MLST
Recombination
Molecular epidemiology
Species complex
Mating-type
Gattii
Serotypes
Genotype
Yayın Tarihi: Şub-2016
Yayıncı: Elsevier
Atıf: Cogliati, M. vd. (2016). "Multilocus sequence typing analysis reveals that Cryptococcus neoformans var. neoformans is a recombinant population". Fungal Genetics and Biology, 87, 22-29.
Özet: Cryptococcus neoformans var. neoformans (serotype D) represents about 30% of the clinical isolates in Europe and is present less frequently in the other continents. It is the prevalent etiological agent in primary cutaneous cryptococcosis as well as in cryptococcal skin lesions of disseminated cryptococcosis. Very little is known about the genotypic diversity of this Cryptococcus subtype. The aim of this study was to investigate the genotypic diversity among a set of clinical and environmental C. neoformans var. neoformans isolates and to evaluate the relationship between genotypes, geographical origin and clinical manifestations. A total of 83 globally collected C neoformans var. neoformans isolates from Italy, Germany, France, Belgium, Denmark, Greece, Turkey, Thailand, Japan, Colombia, and the USA, recovered from different sources (primary and secondary cutaneous cryptococcosis, disseminated cryptococcosis, the environment, and animals), were included in the study. All isolates were confirmed to belong to genotype VNIV by molecular typing and they were further investigated by MLST analysis. Maximum likelihood phylogenetic as well as network analysis strongly suggested the existence of a recombinant rather than a clonal population structure. Geographical origin and source of isolation were not correlated with a specific MLST genotype. The comparison with a set of outgroup C neoformans var. grubii isolates provided clear evidence that the two varieties have different population structures.
URI: https://doi.org/10.1016/j.fgb.2016.01.003
https://www.sciencedirect.com/science/article/pii/S1087184516300020
http://hdl.handle.net/11452/29044
ISSN: 1087-1845
1096-0937
Koleksiyonlarda Görünür:Scopus
Web of Science

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