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Başlık: Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice
Yazarlar: Muldoon, Pretal P.
AiSharari, Shakir
Carroll, F. Ivy
Negus, S. Stevens
Damaj, M. Imad
Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi.
Bağdaş, Deniz
15062425700
Anahtar kelimeler: Neurosciences & neurology
Pharmacology & pharmacy
Acetic acid
Conditioned place aversion
Mice
Pain
Analgesics
Negative affective component
Animal-models
Preclinical assays
Analgesic efficacy
Stria terminalis
Bed nucleus
Morphine
Amygdala
Activation
Depression
Yayın Tarihi: Mar-2016
Yayıncı: Elsevier
Atıf: Bağdaş, D. vd. (2016). "Expression and pharmacological modulation of visceral pain-induced conditioned place aversion in mice". Neuropharmacology, 102, 236-243.
Özet: Pain encompasses both a sensory as well as an affective dimension and these are differentially processed in the brain and periphery. It is therefore important to develop animal models to reflect the non-reflexive assays in pain. In this study, we compared effects of the mu opioid receptor agonist morphine, the nonsteroidal anti-inflammatory drug ketoprofen and the kappa receptor opioid agonist U50,488H and antagonist JDTic on acetic acid-induced stretching and acetic acid-induced aversion in the condition place aversion (CPA) test in male ICR mice. Intraperitoneal administration of acetic acid (0.32-1%) was equipotent in stimulating stretching and CPA. Ketoprofen, morphine and U50,488H all inhibited the acid induced stretching. Ketoprofen and morphine also blocked the acid-induced CPA but U50,488H failed to do so. The reversal ability of ketoprofen and morphine on acid-induced CPA is unique to pain-stimulated place aversion since these drugs failed to reduce non-noxious LiCl-induced CPA. Overall, this study characterized and validated a preclinical mouse model of pain-related aversive behavior that can be used to assess genetic and biological mechanisms of pain as well as improving the predictive validity of preclinical studies on candidate analgesics.
URI: https://doi.org/10.1016/j.neuropharm.2015.11.024
https://www.sciencedirect.com/science/article/pii/S002839081530188X
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574195/
http://hdl.handle.net/11452/29218
ISSN: 0028-3908
1873-7064
Koleksiyonlarda Görünür:Scopus
Web of Science

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