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Başlık: The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro
Yazarlar: Botta, Bruno
Mori, Mattia
Berardozzi, Simone
Ingallina, Cinzia
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.
Cevatemre, Buse
Ulukaya, Engin
AHD-2050-2022
K-5792-2018
55693788600
6602927353
Anahtar kelimeler: Biochemistry & molecular biology
Pharmacology & pharmacy
Toxicology
Tingenone
Breast
ER stress
Chemotherapy
Malignancy
Mammosphere
Endoplasmic-reticulum
Prospective identification
Natural-products
Tissue-cultures
Ursolic acid
Bcl-2 family
Stress
Pristimerin
Apoptosis
Subpopulation
Yayın Tarihi: 25-Ara-2016
Yayıncı: Elsevier
Atıf: Cevatemre, B. vd. (2016). "The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro". Chemico-Biological Interactions, 260, 248-255.
Özet: Despite the rapid advances in chemotherapy regimens, the outcome of patients with breast cancer is not satisfactory. One of the reasons of this dissatisfaction is that subsets of cells in tumors which referred as cancer stem cells (CSCs) show and/or gain resistance to therapies. Thus, compounds that target CSCs are urgently needed. Since some are already used in the clinic, natural products have great potential for further development as anti cancer drugs. The aim of this study is to investigate the cytotoxic activity of tingenin b (or 22 beta-hydroxytingenone) which is a quinone-methide triterpenoid structurally related to tingenone, against breast CSCs (stem-cell enriched population from MCF-7 cell line, MCF-7s). It has been found that tingenin b was cytotoxic against MCF-7s (IC50 value for 48 h was found to be 2.38 mu M) by inducing apoptosis. It was evident by Annexin V staining positivity, decreased mitochondria( membrane potential and Bcl-2 dephosphorylation with a concomitant increase in Bax protein expression. In addition, endoplasmic reticulum stress was also found to be involved in tingenin b-induced cell death. In conclusion, the results warrant further studies aimed at elucidating and corroborating its possible use in the treatment of breast cancer.
URI: https://doi.org/10.1016/j.cbi.2016.10.001
https://www.sciencedirect.com/science/article/pii/S0009279716304239
http://hdl.handle.net/11452/29246
ISSN: 0009-2797
1872-7786
Koleksiyonlarda Görünür:Scopus
Web of Science

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