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Başlık: Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus)
Yazarlar: Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
0000-0002-6729-7908
Dere, Egemen
Arı, Ferda Özdikicioğlu
Tosunoğlu, Hakan
AAH-5068-2021
AAG-7012-2021
6603627015
6504081459
23478447500
Anahtar kelimeler: ALP
Rattus
Rattus norvegicus
ALT
AST
DNOC
LDH
Rat
Veterinary sciences
Cyprinus-carpio L.
Liver
Pesticides
Exposure
Benzene
Enzymes
Tissues
Yayın Tarihi: 2007
Yayıncı: Sciendo
Atıf: Dere, E. vd. (2007). "Hepatotoxicity of Dinitro-o-cresol in rats (Rattus norvegicus)". Acta Veterinaria-Beograd, 57(5-6), 497-507.
Özet: In this study we investigated the hepatotoxic effect of DNOC in rats, using biochemical serum parameters as indicators of liver disease. Experimental groups were injected intraperitoneally with 2.8 mg/kg DNOC. While an increase was determined in LDH activities for all periods, an increase was determined for urea values only up to 16 hours. In general, increased AST and ALP activities were recorded up to the 8(th) hour. Thereof, at later periods inhibition was observed. Inhibition was observed in female rats, while ALT activation was observed in male rats. Amylase activity inhibition was observed in both groups. Increased values were observed for cholesterol and HDL at the initial hours. No significant changes were observed in triglyceride levels. As a result, it has been observed that DNOC caused changes in serum enzyme activities and in biochemical parameters in female and male rats.
URI: http://www.doiserbia.nb.rs/img/doi/0567-8315/2007/0567-83150706497D.pdf
https://doi.org/10.2298/AVB0706497D
http://hdl.handle.net/11452/29267
ISSN: 0567-8315
1820-7448
Koleksiyonlarda Görünür:Scopus
Web of Science

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