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Başlık: Paraoxonase activity in glomerulonephritic patients
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.
0000-0002-0710-0923
Güllülü, Mustafa
Kahvecioğlu, Serdar
Dirican, Melahat
Akdağ, İbrahim
Ocak, Nihal
Demircan, Celalettin
Dilek, Kamil
Ersoy, Alpaslan
Yavuz, Mahmut
Yurtkuran, Mustafa
AAG-6985-2021
AAH-5054-2021
6602684544
55956719500
6601919847
8342488100
23989248600
6507741676
56005080200
35612977100
7006244754
7003389525
Anahtar kelimeler: Glomerulonephritis
Low-density-lipoprotein
Urology & nephrology
Lipid
Oxidation
Paraoxonase
Urinary paraoxonase
Uremic patients
Oxidized ldl
Arylesterase
Decrease
Disease
Cells
Yayın Tarihi: 2007
Yayıncı: Taylor & Francis
Atıf: Güllülü, M. vd. (2007). "Paraoxonase activity in glomerulonephritic patients". Renal Failure, 29(4), 433-439.
Özet: Background. Cardiovascular disease is the most common cause of morbidity and mortality in patients with chronic renal failure. Glomerulonephritic patients have an increased risk for cardiovascular disease, but its etiology is unclear. It is known that an increase in oxidizability of apolipoprotein B-containing lipoproteins has a key role in the initiation of atherosclerosis, and paraoxonase enzyme activity particularly has a preventive role against atherosclerosis. The aim of the present study was to evaluate the oxidizability of apolipoprotein B-containing lipoproteins, serum, and urinary paraoxonase/arylesterase activities in g] omerulonephritis patients who had normal lipid parameters and creatinine levels. Methods. Thirty-two patients with glomerulonephritis and 22 healthy controls were included in this study. A total of 32 patients (including nine with membranous GN, eight with immunoglobulin A nephropathy, eight with mesangial prolifferative GN, five with focal-segmental glomerulosclerosis, one with diffuse proliferative GN, and one with minimal chance disease having biopsy proven GN) were enrolled into the study. We compared serum and urinary paraoxonase, arylesterase, serum lipids, urea, creatinine, hemoglobin, total protein and albumin values between groups. Results. Serum urea, creatinine, total protein, albumin, uric acid, hemoglobin, and lipid parameters were similar in the glomerulonephritis and control groups (p > 0.05). PON1 activity was significantly lower in GN group nan controls, but there was no statistically significant difference on arylesterase activity between groups. Oxidizability of apolipoprotein B-containing lipoproteins was significantly higher in GN group than controls. Conclusion. Our study shows that the findings of normal serum levels of creatinine, lipids, and protieins increased the oxidizability of apolipoprotein B-containing lipo-proteins, and any decrease in PON1 activity in patients diagnosed with GN should be considered important. Hence, the immediate commencement of preventive as well as curative treatment in other to avoid the risk of cardiovascular and renal problems would be a correct approach.
URI: https://doi.org/10.1080/08860220701278216
https://www.tandfonline.com/doi/full/10.1080/08860220701278216
http://hdl.handle.net/11452/29314
ISSN: 1525-6049
0886-022X
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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