Enzymatic generation of highly anticoagulant bovine intestinal heparin

Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29361

Title:	Enzymatic generation of highly anticoagulant bovine intestinal heparin
Authors:	Fu, Li Li, Kevin Hirakane, Makoto Lin, Lei Grover, Navdeep Datta, Payel Yu, Yanlei Zhao, Jing Zhang, Fuming Mousa, Shaker A. Dordick, Jonathan S. Linhardt, Robert J. Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı. 0000-0002-5600-8162 Yalçın, Murat AAG-6956-2021 57192959734
Keywords:	Pharmacology & pharmacy Molecular-weight heparins Chemoenzymatic synthesis Induced thrombocytopenia Pharmaceutical heparins Chondroitin sulfate Porcine Binding Tissues Drugs
Issue Date:	26-Oct-2017
Publisher:	Amer Chemical
Citation:	Fu, L. vd. (2017). ''Enzymatic generation of highly anticoagulant bovine intestinal heparin''. Journal of Medicinal Chemistry, 60(20), 8673-8679.
Abstract:	Unlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1,-3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.
URI:	https://doi.org/10.1021/acs.jmedchem.7b01269 https://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01269?cookieSet=1 http://hdl.handle.net/11452/29361
ISSN:	0022-2623 1520-4804
Appears in Collections:	Scopus Web of Science

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