1. Açık Erişim@BUU
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Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29448
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dc.contributor.authorZorlu, Tolga-
dc.date.accessioned2022-11-10T08:38:41Z-
dc.date.available2022-11-10T08:38:41Z-
dc.date.issued2013-03-
dc.identifier.citationÇinkılıç, N. vd. (2013). "Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro". Food and Chemical Toxicology, 53, 359-363.en_US
dc.identifier.issn0278-6915-
dc.identifier.issn1873-6351-
dc.identifier.urihttps://doi.org/10.1016/j.fct.2012.12.008-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0278691512008782-
dc.identifier.urihttp://hdl.handle.net/11452/29448-
dc.description.abstractThe present study was designed to determine the radioprotective effect of two phytochemicals, namely, quinic acid and chlorogenic acid, against X-ray irradiation-induced genomic instability in non-tumorigenic human blood lymphocytes. The protective ability of two phenolic acids against radiation-induced DNA damage was assessed using the alkaline comet assay in human blood lymphocytes isolated from two healthy human donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for irradiation. The results of the alkaline comet assay revealed that quinic acid and chlorogenic acid decreased the DNA damage induced by X-ray irradiation and provided a significant radioprotective effect. Quinic acid decreased the presence of irradiation-induced DNA damage by 5.99-53.57% and chlorogenic acid by 4.49-48.15%, as determined by the alkaline comet assay. The results show that quinic acid and chlorogenic acid may act as radioprotective compounds. Future studies should focus on determining the mechanism by which these phenolic acids provide radioprotection.en_US
dc.publisherPergamon-Elsevier Scienceen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFood science & technologyen_US
dc.subjectToxicologyen_US
dc.subjectRadioprotectionen_US
dc.subjectChlorogenic aciden_US
dc.subjectQuinic aciden_US
dc.subjectX-ray irradiationen_US
dc.subjectComet assayen_US
dc.subjectDNA damageen_US
dc.subjectCultured human-lymphocytesen_US
dc.subjectGamma-radiationen_US
dc.subjectCaffeic aciden_US
dc.subjectLipid-peroxidationen_US
dc.subjectAntioxidant activitiesen_US
dc.subjectDerivativesen_US
dc.subjectCellsen_US
dc.subjectCarcinogenesisen_US
dc.subjectFlavonoidsen_US
dc.subjectMechanismen_US
dc.subject.meshAdulten_US
dc.subject.meshChlorogenic aciden_US
dc.subject.meshComet assayen_US
dc.subject.meshDNA damageen_US
dc.subject.meshDose-response relationship, drugen_US
dc.subject.meshDose-response relationship, radiationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphocytesen_US
dc.subject.meshMaleen_US
dc.subject.meshQuinic aciden_US
dc.subject.meshRadiation-protective agentsen_US
dc.subject.meshX-raysen_US
dc.subject.meshYoung adulten_US
dc.titleRadioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitroen_US
dc.typeArticleen_US
dc.identifier.wos000322924700049tr_TR
dc.identifier.scopus2-s2.0-84872392997tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.tr_TR
dc.relation.bapF (U)-2009/39tr_TR
dc.contributor.orcid0000-0002-3595-6286tr_TR
dc.contributor.orcid0000-0002-7687-3284tr_TR
dc.identifier.startpage359tr_TR
dc.identifier.endpage363tr_TR
dc.identifier.volume53tr_TR
dc.relation.journalFood and Chemical Toxicologyen_US
dc.contributor.buuauthorÇinkılıç, Nilüfer-
dc.contributor.buuauthorÇetintaş, Sibel Kahraman-
dc.contributor.buuauthorVatan, Özgür-
dc.contributor.buuauthorYılmaz, Dilek-
dc.contributor.buuauthorÇavaş, Tolga-
dc.contributor.buuauthorTunç, Sema-
dc.contributor.buuauthorÖzkan, Lütfi-
dc.contributor.buuauthorBilaloǧlu, Rahmi-
dc.contributor.researcheridAAH-3508-2021tr_TR
dc.contributor.researcheridAAH-5296-2021tr_TR
dc.contributor.researcheridO-7508-2015tr_TR
dc.contributor.researcheridAAA-7047-2020tr_TR
dc.relation.collaborationYurt içitr_TR
dc.identifier.pubmed23266271tr_TR
dc.subject.wosFood science & technologyen_US
dc.subject.wosToxicologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1 (Food science & technology)en_US
dc.wos.quartileQ2 (Toxicology)en_US
dc.contributor.scopusid26533892300tr_TR
dc.contributor.scopusid6505881756tr_TR
dc.contributor.scopusid16235098100tr_TR
dc.contributor.scopusid6701369462tr_TR
dc.contributor.scopusid6602989548tr_TR
dc.contributor.scopusid55557323500tr_TR
dc.contributor.scopusid55915679400tr_TR
dc.contributor.scopusid6505804122tr_TR
dc.subject.scopusAntioxidant; Carlina Oxide; Loniceraen_US
dc.subject.emtreeChlorogenic aciden_US
dc.subject.emtreeQuinic aciden_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCell protectionen_US
dc.subject.emtreeComet assayen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDNA damageen_US
dc.subject.emtreeGenomic instabilityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeIn vitro studyen_US
dc.subject.emtreeLymphocyteen_US
dc.subject.emtreeNormal humanen_US
dc.subject.emtreeRadiation protectionen_US
dc.subject.emtreeX rayen_US
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