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Başlık: Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro
Yazarlar: Zorlu, Tolga
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.
0000-0002-3595-6286
0000-0002-7687-3284
Çinkılıç, Nilüfer
Çetintaş, Sibel Kahraman
Vatan, Özgür
Yılmaz, Dilek
Çavaş, Tolga
Tunç, Sema
Özkan, Lütfi
Bilaloǧlu, Rahmi
AAH-3508-2021
AAH-5296-2021
O-7508-2015
AAA-7047-2020
26533892300
6505881756
16235098100
6701369462
6602989548
55557323500
55915679400
6505804122
Anahtar kelimeler: Food science & technology
Toxicology
Radioprotection
Chlorogenic acid
Quinic acid
X-ray irradiation
Comet assay
DNA damage
Cultured human-lymphocytes
Gamma-radiation
Caffeic acid
Lipid-peroxidation
Antioxidant activities
Derivatives
Cells
Carcinogenesis
Flavonoids
Mechanism
Yayın Tarihi: Mar-2013
Yayıncı: Pergamon-Elsevier Science
Atıf: Çinkılıç, N. vd. (2013). "Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro". Food and Chemical Toxicology, 53, 359-363.
Özet: The present study was designed to determine the radioprotective effect of two phytochemicals, namely, quinic acid and chlorogenic acid, against X-ray irradiation-induced genomic instability in non-tumorigenic human blood lymphocytes. The protective ability of two phenolic acids against radiation-induced DNA damage was assessed using the alkaline comet assay in human blood lymphocytes isolated from two healthy human donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for irradiation. The results of the alkaline comet assay revealed that quinic acid and chlorogenic acid decreased the DNA damage induced by X-ray irradiation and provided a significant radioprotective effect. Quinic acid decreased the presence of irradiation-induced DNA damage by 5.99-53.57% and chlorogenic acid by 4.49-48.15%, as determined by the alkaline comet assay. The results show that quinic acid and chlorogenic acid may act as radioprotective compounds. Future studies should focus on determining the mechanism by which these phenolic acids provide radioprotection.
URI: https://doi.org/10.1016/j.fct.2012.12.008
https://www.sciencedirect.com/science/article/pii/S0278691512008782
http://hdl.handle.net/11452/29448
ISSN: 0278-6915
1873-6351
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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