Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/29554
Title: Advances and recent developments in asthma in 2020
Authors: Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.
0000-0003-2287-3569
Cevhertaş, Laçin
57216918051
Keywords: Asthma biomarkers
Asthma phenotypes
Biological therapeutics
Comorbidities
Covid-19
Allergen immunotherapy
Arginase inhibitors
Blood eosinophils
Eeeaci guidelines
Food allergy
Rhinits
Management
Omalizumab
Pathology
Paradigm
Allergy
Immunology
Issue Date: 30-Sep-2020
Publisher: Wiley
Citation: Cevhertaş, L. vd. (2020). "Advances and recent developments in asthma in 2020". Allergy: European Journal of Allergy and Clinical Immunology, 75(12), 3124-3146.
Abstract: In this review, we discuss recent publications on asthma and review the studies that have reported on the different aspects of the prevalence, risk factors and prevention, mechanisms, diagnosis, and treatment of asthma. Many risk and protective factors and molecular mechanisms are involved in the development of asthma. Emerging concepts and challenges in implementing the exposome paradigm and its application in allergic diseases and asthma are reviewed, including genetic and epigenetic factors, microbial dysbiosis, and environmental exposure, particularly to indoor and outdoor substances. The most relevant experimental studies further advancing the understanding of molecular and immune mechanisms with potential new targets for the development of therapeutics are discussed. A reliable diagnosis of asthma, disease endotyping, and monitoring its severity are of great importance in the management of asthma. Correct evaluation and management of asthma comorbidity/multimorbidity, including interaction with asthma phenotypes and its value for the precision medicine approach and validation of predictive biomarkers, are further detailed. Novel approaches and strategies in asthma treatment linked to mechanisms and endotypes of asthma, particularly biologicals, are critically appraised. Finally, due to the recent pandemics and its impact on patient management, we discuss the challenges, relationships, and molecular mechanisms between asthma, allergies, SARS-CoV-2, and COVID-19.
Description: Bu çalışmada 22 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır.
URI: https://onlinelibrary.wiley.com/doi/full/10.1111/all.14607
https://doi.org/10.1111/all.14607
http://hdl.handle.net/11452/29554
ISSN: 0105-4538
Appears in Collections:PubMed
Scopus
Web of Science

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