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Başlık: Tolerance mechanisms in allergen immunotherapy
Yazarlar: Sözener, Zeynep Çelebi
Mungan, Dilşad
Öğülür, İsmail
Akdiş, Mübeccel
Akdiş, Cezmi
Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.
Cevhertaş, Laçin
FYD-1431-2022
57216918051
Anahtar kelimeler: Allergy
Immunology
Allergen immunotherapy
B regs
Interleukin-10
Innate lymphoid cell regs
Immune tolerance
Tregs
Grass-pollen immunotherapy
Innate lymphoid-cells
Regulatory b-cells
House-dust mite
Immune tolerance
Sublingual immunotherapy
Dendritic cells
T-cells
Clinical-efficacy
EAACI guidelines
Yayın Tarihi: Ara-2020
Yayıncı: Lippincott Williams & Wilkins
Atıf: Sözener, Z. Ç. vd. (2020). "Tolerance mechanisms in allergen immunotherapy". Current Opinion in Allergy and Clinical Immunology, 20(6), 591-601.
Özet: Purpose of review Allergen immunotherapy is the only treatment modality which alters the natural course of allergic diseases by restoring immune tolerance against allergens. Deeper understanding of tolerance mechanisms will lead to the development of new vaccines, which target immune responses and promote tolerance. Recent findings Successful allergen immunotherapy (AIT) induces allergen-specific peripheral tolerance, characterized mainly by the generation of allergen-specific Treg cells and reduction of Th2 cells. At the early phase, AIT leads to a decrease in the activity and degranulation of mast cells and basophils and a decrease in inflammatory responses of eosinophils in inflamed tissues. Treg cells show their effects by secreting inhibitory cytokines including interleukin (IL)-10, transforming growth factor-beta, interfering with cellular metabolisms, suppressing antigen presenting cells and innate lymphoid cells (ILCs) and by cytolysis. AIT induces the development of regulatory B cells producing IL-10 and B cells expressing allergen-specific IgG4. Recent investigations have demonstrated that AIT is also associated with the formation of ILC2reg and DCreg cells which contribute to tolerance induction. Research done so far, has shown that multiple molecular and cellular factors are dysregulated in allergic diseases and modified by AIT. Studies should now focus on finding the best target and ideal biomarkers to identify ideal candidates for AIT.
URI: https://doi.org/10.1097/ACI.0000000000000693
https://journals.lww.com/co-allergy/Fulltext/2020/12000/Tolerance_mechanisms_in_allergen_immunotherapy.8.aspx
http://hdl.handle.net/11452/29952
ISSN: 1528-4050
1473-6322
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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