Bu öğeden alıntı yapmak, öğeye bağlanmak için bu tanımlayıcıyı kullanınız: http://hdl.handle.net/11452/29964
Başlık: Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats
Yazarlar: Jochem, Jerzy
Ottani, Alessandra
Giuliani, Daniela
Kasperska-Zajac, Alicja
Guarini, Salvatore
Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.
0000-0002-5600-8162
Altınbaş, Burçin
Yalçın, Murat
Savcı, Vahide
AAG-6956-2021
55356919300
57192959734
6603687024
Anahtar kelimeler: Physiology
Histaminergic system
Leptin
Haemorrhagic shock
Mean arterial pressure
Heart rate
Histamine receptor antagonist
Arterial-pressure
Induced reversal
Hypotension
Responses
Vasopressin
Mechanisms
Receptor
Release
Ischemia/reperfusion
Proopiomelanocortin
Yayın Tarihi: Şub-2016
Yayıncı: Polish Physiological
Atıf: Jochem, J. vd. (2016). "Involvement of the histaminergic system in the resuscitating effect of centrally acting leptin in haemorrhagic shock in rats". Journal of Physiology and Pharmacology, 67(1), 67-74.
Özet: Leptin, acting centrally as a neuromodulator, induces the activation of the sympathetic nervous system, which may lead to a pressor action in normotensive animals. In haemorrhagic shock, leptin administered intracerebroventricularly (icv.) evokes the resuscitating effect, with long-lasting rises in mean arterial pressure (MAP) and heart rate (HR), subsequent increase in peripheral blood flows, and a 100% survival at 2 h. Since leptin is able to activate histaminergic neurons, and centrally acting histamine also induces the resuscitating effect with the activation of the sympathetic nervous system, in the present study, we investigated an involvement of the histaminergic system in leptin-evoked cardiovascular effects in haemorrhagic shock. The model of irreversible haemorrhagic shock, with MAP decreased to and stabilised at 20 - 25 mmHg, has been used. Leptin (20 mu g) given icv. at 5 min of critical hypotension evoked 181.5% increase in extracellular hypothalamic histamine concentration during the first 10 min after injection. Rises in MAP, HR and renal, mesenteric and hindquarters blood flows induced by leptin were inhibited by icv. pre-treatment with histamine H-1 receptor antagonist chlorpheniramine (50 nmol). In contrast, there was no effect of H-2, H-3 and H-4 receptor antagonists ranitidine (25 nmol), VUF 5681 (25 nmol) and JNJ 10191584 (25 nmol), respectively. In conclusion, the histaminergic system is involved in centrally-acting leptin-induced resuscitating effect in haemorrhagic shock in rats.
URI: https://doi.org/000373380100006
https://www.jpp.krakow.pl/
http://hdl.handle.net/11452/29964
ISSN: 0867-5910
Koleksiyonlarda Görünür:Scopus
Web of Science

Bu öğenin dosyaları:
Bu öğeyle ilişkili dosya bulunmamaktadır.


DSpace'deki bütün öğeler, aksi belirtilmedikçe, tüm hakları saklı tutulmak şartıyla telif hakkı ile korunmaktadır.