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Başlık: Investigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosis
Yazarlar: Yolbaş, Servet
Çetin, Gözde Yıldırım
Alibaz, Fatma Öner
Çağatay, Yonca
Yılmaz, Neslihan
Öztuzcu, Serdar
Dönmez, Salim
Özgen, Metin
Koca, Süleyman Serdar
Pamuk, Ömer Nuri
Sayarlıoğlu, Mehmet
Kısacık, Bünyamin
Direskeneli, Haner
Demiryürek, Abdullah Tuncay
Onat, Ahmet Mesut
Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Bilim Dalı.
Pehlivan, Yavuz
AAG-8227-2021
13205593600
Anahtar kelimeler: Rheumatology
Systemic sclerosis
Pathogenesis
Rho/Rho-kinase
Early diagnosis
Rho-kinase
Urotensin-II
Pulmonary-hypertension
Endothelin
Receptor
Scleroderma
Fibrosis
Differentiation
Vasoconstrictor
Inhibition
Yayın Tarihi: 17-Kas-2015
Yayıncı: Springer
Atıf: Pehlivan, Y. vd. (2016). "Investigation of the association between Rho/Rho-kinase gene polymorphisms and systemic sclerosis". Rheumatology International, 36(3), 421-427.
Özet: Systemic sclerosis (SSc) is a disease characterized by inflammation, vascular abnormalities and fibrosis. The role of Rho/Rho-kinase pathway was demonstrated in the pathogenesis of fibrosis, inflammation and vascular abnormalities. This study was aimed to investigate the relation between SSc and Rho/Rho-kinase gene polymorphisms. The study included 339 patients with SSc and 302 healthy subjects who were apparently healthy and at similar age and gender. Genotype distributions and allele frequencies were detected by using Chi-square test or Fisher's exact Chi-square test between groups, and the haplotype analysis was applied using online program (SHEsis). Significant association was found in a polymorphism in the ROCK1 gene (rs35996865), a polymorphism in ROCK2 gene (rs10178332), a polymorphism in RhoA gene (rs2177268) and two polymorphisms in RhoC gene (rs11102522 and rs11538960) with SSc disease (p < 0.0022). In this study, association between SSc disease and Rho/Rho-kinase gene polymorphisms was investigated for the first time; significant associations between ROCK1, ROCK2, RhoA and RhoC gene polymorphisms and SSc disease were demonstrated. The results strongly suggest that this SNP may be an important risk factor for development of SSc. However, further validation of these findings in an independent cohort is necessary.
URI: https://doi.org/10.1007/s00296-015-3400-4
https://link.springer.com/article/10.1007/s00296-015-3400-4
http://hdl.handle.net/11452/29978
ISSN: 0172-8172
1437-160X
Koleksiyonlarda Görünür:Scopus
Web of Science

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