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Başlık: Long-term cognitive effects of uridine treatment in a neonatal rat model of hypoxic-ischemic encephalopathy
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.
0000-0001-7729-7373
0000-0002-3405-3640
0000-0001-6466-5042
0000-0003-0841-8201
0000-0003-2918-5064
Gören, Bülent
Çakır, Aysen
Öçalan, Buşra
Koçoğlu, Sema Serter
Alkan, Tülin
Cansev, Mehmet
Kahveci, Nevzat
A-6819-2018
M-9071-2019
AAH-1718-2021
N-9927-2019
AAH-1792-2021
AAG-7070-2021
0000-0001-6466-5042
6602543716
57191915856
57191911801
57193141905
6601953747
8872816100
6602597846
Anahtar kelimeler: Neurosciences & neurology
Behavior
Hypoxic-ischemic
Encephalopathy
Learning and memory
Neonatal rat
Uridine
Brain-injury
Water-maze
Behavioral deficits
Impoverished rats
Magnesium-sulfate
Animal-model
Protects
Memory
Damage
Melatonin
Yayın Tarihi: 20-Oca-2017
Yayıncı: Elsevier
Atıf: Gören, B. vd. (2017). ''Long-term cognitive effects of uridine treatment in a neonatal rat model of hypoxic-ischemic encephalopathy''. Brain Research, 1659, 81-87.
Özet: Hypoxic-ischemic encephalopathy (HIE), is the most common brain disorder in neonates during the perinatal period, which, to date, can only be managed to some extent by hypothermia. Uridine is the principal circulating pyrimidine in humans which is utilized as a precursor for membrane phospholipid biosynthesis. Uridine has recently been shown to provide clinical benefit in treatment of Alzheimer's disease due to its involvement in increasing number of brain synapses along with other phospholipid precursors. We previously showed that uridine treatment ameliorated brain damage by reducing apoptosis in a rat model of neonatal HIE. The aim of the present study was to investigate the effects of uridine administration on cognitive functions during periadolescent period in rats subjected to hypoxic-ischemic (HI) brain damage in neonatal period. Male newborn rats were subjected to HI insult on postnatal day 7 (P7) and were injected intraperitoneally with either saline or uridine (500 mg/kg) for three consecutive days. Part of pups in each group were sacrificed on P10 to collect brain samples for active Caspase-3 analyses and the remaining pups were raised through P40 to evaluate early reflexes, sensorimotor coordination and learning and memory functions by Negative Geotaxis (NG), Beam Walking (BW) and Morris Water Maze (MWM) tasks, respectively. Confirming our previous findings, we showed that uridine administration reduced apoptotic cell damage on P10. No significant difference was observed between uridine and saline groups in early reflexes or sensorimotor coordination. On the other hand, rats receiving uridine displayed improved learning and memory in MWM during periadolescent period. We conclude that uridine treatment improves learning and memory in the long term by, probably, reducing apoptotic cell death in early newborn period. This is the first study to show beneficial cognitive effects of uridine in rats with brain damage.
URI: https://doi.org/10.1016/j.brainres.2017.01.026
https://www.sciencedirect.com/science/article/pii/S0006899317300409
1872-6240
http://hdl.handle.net/11452/30159
ISSN: 0006-8993
Koleksiyonlarda Görünür:Scopus
Web of Science

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