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Başlık: Fluorinated analog NMR s of organosulfur compounds from garlic (allium sativum): Synthesis, chemistry and anti-angiogenesis and antithrombotic studies
Yazarlar: Block, Eric
Bechand, Benjamin
Gundala, Sivaji
Vattekkatte, Abith
Wang, Kai
Mousa, Shaymaa S
Godugu, Kavitha
Mousa, Shaker A.
Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.
0000-0002-5600-8162
Yalçın, Murat
AAG-6956-2021
57192959734
Anahtar kelimeler: Biochemistry & molecular biology
Chemistry
2-fluoroallyl sulfur compounds
Ajoene
Allicin
Angiogenesis
Anti-angiogenesis
Anti-thrombotic
Coagulation
Difluoroallicin
Garlic
Platelet
Thrombosis
Trifluoroajoene
Vinyl dithiins
In-vitro
Allicin
Efficacy
Polymerization
Derivatives
Antagonists
Dynamics
Stress
Acid
Yayın Tarihi: 24-Kas-2017
Yayıncı: MDPI
Atıf: Block, E. vd. (2017). ''Fluorinated analog NMR s of organosulfur compounds from garlic (allium sativum): Synthesis, chemistry and anti-angiogenesis and antithrombotic studies''. Molecules, 22(12).
Özet: We describe the synthesis, reactivity, and antithrombotic and anti-angiogenesis activity of difluoroallicin (S-(2-fluoroallyl) 2-fluoroprop-2-ene-1-sulfinothioate) and S-2-fluoro-2-propenyl-l-cysteine, both easily prepared from commercially available 3-chloro-2-fluoroprop-1-ene, as well as the synthesis of 1,2-bis(2-fluoroallyl)disulfane, 5-fluoro-3-(1-fluorovinyl)-3,4-dihydro-1,2-dithiin, trifluoroajoene ((E,Z)-1-(2-fluoro-3-((2-fluoroallyl)sulfinyl)prop-1-en-1-yl)-2-(2-fluoroallyl)disulfane), and a bis(2-fluoroallyl)polysulfane mixture. All tested organosulfur compounds demonstrated effective inhibition of either FGF or VEG-mediated angiogenesis (anti-angiogenesis activity) in the chick chorioallantoic membrane (CAM) or the mouse Matrigel (R) models. No embryo mortality was observed. Difluoroallicin demonstrated greater inhibition (p < 0.01) versus organosulfur compounds tested. Difluoroallicin demonstrated dose-dependent inhibition of angiogenesis in the mouse Matrigel (R) model, with maximal inhibition at 0.01 mg/implant. Allicin and difluoroallicin showed an effective antiplatelet effect in suppressing platelet aggregation compared to other organosulfur compounds tested. In platelet/fibrin clotting (anti-coagulant activity), difluoroallicin showed concentration-dependent inhibition of clot strength compared to allicin and the other organosulfur compounds tested.
URI: https://doi.org/10.3390/molecules22122081
https://www.mdpi.com/1420-3049/22/12/2081
1420-3049
http://hdl.handle.net/11452/30161
Koleksiyonlarda Görünür:Scopus
Web of Science

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