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http://hdl.handle.net/11452/30284
Başlık: | Effects of nicotine metabolites on nicotine withdrawal behaviors in mice |
Yazarlar: | Elhassan, Sagi Damaj, M.Imad Uludağ Üniversitesi/Tıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Merkezi. Bağdaş, Deniz 15062425700 |
Anahtar kelimeler: | Substance abuse Public, environmental & occupational health Minor tobacco alkaloids Drug discrimination Nornicotine Cotinine |
Yayın Tarihi: | Haz-2017 |
Yayıncı: | Oxford University |
Atıf: | Elhassan, S. vd. (2017). ''Effects of nicotine metabolites on nicotine withdrawal behaviors in mice''. Nicotine and Tobacco Research, 19(6), 763-766. |
Özet: | Introduction: Rodent studies suggest that nicotine metabolites and minor tobacco alkaloids such as nornicotine and cotinine may promote cigarette smoking by enhancing nicotine rewarding and reinforcing effects. However, there is little information on the effects of these minor tobacco alkaloids on nicotine withdrawal. The present studies were conducted to determine whether the minor tobacco alkaloids nornicotine and cotinine exhibit nicotine-like behavioral effects in a mouse model of spontaneous nicotine withdrawal. Methods: Mice were infused with nicotine or saline for 14 days. Experiments were conducted on day 15, 18-24 hours after minipump removal. Ten minutes prior to testing, nicotine-dependent ICR male mice received an acute injection of nicotine (0.05 and 0.5 mg/kg), nornicotine (2.5 and 25 mg/kg), or cotinine (5 and 50 mg/kg) to determine effects on somatic signs, anxiety-like behaviors, and hyperalgesia spontaneous signs of withdrawal. Results: Nicotine and the minor tobacco alkaloid nornicotine, but not cotinine, produced dose-dependent reversal of nicotine withdrawal signs in the mouse. Implications: The minor tobacco alkaloid and nicotine metabolite nornicotine at high doses have nicotinic like effects that may contribute to tobacco consumption and dependence. |
URI: | https://doi.org/10.1093/ntr/ntx045 https://academic.oup.com/ntr/article/19/6/763/2983610?login=true 1469-994X http://hdl.handle.net/11452/30284 |
ISSN: | 1462-2203 |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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