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Başlık: Low serum IGF-1 and increased cytokine levels in tracheal aspirate samples are associated with bronchopulmonary dysplasia
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Neonatoloji Anabilim Dalı.
0000-0002-2823-8454
Yılmaz, Cansu
Köksal, Nilgün
Özkan, Hilal
Dorum, Bayram Ali
Bağcı, Onur
A-5375-2017
AAG-8393-2021
57209112906
7003323615
16679325400
37661266800
20733563300
Anahtar kelimeler: Pediatrics
Bronchopulmonary dysplasia
Cytokines
Premature
Tracheal aspirate fluid
IGF-1
Chronic lung-disease
Birth-weight infants
Respiratory-distress-syndrome
Bronchoalveolar lavage fluid
Necrosis-factor-alpha
Growth-factor-I
Premature-infants
Preterm infants
Il-8 expression
Complications
Yayın Tarihi: 20-Şub-2017
Yayıncı: Türk Pediatri Dergisi
Atıf: Yılmaz, C. vd. (2017). ''Low serum IGF-1 and increased cytokine levels in tracheal aspirate samples are associated with bronchopulmonary dysplasia''. Turkish Journal of Pediatrics, 59(2), 122-129.
Özet: Despite developments in the perinatal and neonatal care, bronchopulmonary dysplasia (BPD) is still the most frequently seen long-term complication in preterm infants. The aim of this prospective study is to investigate the association between the development of BPD and serial measurements of IGF-1 levels and their relationship with levels of IGF-1 and cytokine in tracheal aspirate fluids. A total of 40 premature infants, born at a gestational age of <= 32 weeks, were enrolled in the study. On postnatal day-1, 3, 7, 21 and 28 serum IGF-1 levels and IGF-1 levels, IL-6, IL-8, IL-10 and TNF-alpha levels in tracheal aspirate fluid samples of intubated cases were examined. Mean gestational age of 40 patients included in the study was 29.41 +/- 2.23 weeks, and their mean birth weight was 1,256.85 +/- 311.48 g. BPD was detected in 35% of cases. Mean gestational week and birth weight of the cases that developed BPD were 30 +/- 3 weeks and 1,150 +/- 295 g, respectively. Serum IGF-1 levels on postnatal day-1, 3, 7, 21 and 28 in cases who developed BPD were significantly lower when compared with those without BPD (p<0.01). Levels of IL-6, IL-8, IL-10, and TNF-alpha in tracheal aspirate samples were significantly higher in cases with BPD compared to those without BPD (p<0.05). IGF-1 levels in tracheal aspirate fluid samples did not differ significantly based on the presence of BPD (p>0.05). Severity of BPD was associated with decreased serum IGF-1 levels and increased cytokine levels in tracheal aspirate samples.
URI: https://doi.org/10.24953/turkjped.2017.02.003
http://www.turkishjournalpediatrics.org/abstract.php?id=1692
http://hdl.handle.net/11452/30476
ISSN: 0041-4301
Koleksiyonlarda Görünür:Scopus
TrDizin
Web of Science

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