Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30516
Title: Evaluation of arterial stiffness and cardiac function in patients with vascular erectile dysfunction: Acute effects of phosphodiesterase-5 inhibitor tadalafil
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.
0000-0002-8974-8837
0000-0001-8404-8252
Özdabakoǧlu, Osman
Güllülü, Sümeyye
Saǧ, Saim
Şentürk, T.
Kılıçarslan, Hakan
Tütüncü, Ahmet S.
Keçebaş, Mesut
Baran, İbrahim
Aydınlar, Ali
AAI-6632-2021
AAW-9185-2020
25221805700
57204660708
12140008100
8342098300
56007473800
7004229025
36198369900
35572557400
6603131517
Keywords: Urology & nephrology
Ischemic-heart-disease
Pulse-wave velocity
Pressure
Men
Issue Date: 3-Oct-2016
Publisher: Springernature
Citation: Özdabakoğlu, O. vd. (2017). ''Evaluation of arterial stiffness and cardiac function in patients with vascular erectile dysfunction: Acute effects of phosphodiesterase-5 inhibitor tadalafil''. International Journal of Impotence Research, 29(3), 96-100.
Abstract: This study aimed to detect endothelial dysfunction in erectile dysfunction (ED) patients free from cardiovascular diseases or atherosclerotic risk factors and to evaluate acute effects of phosphodiesterase-5 inhibitor tadalafil on endothelial dysfunction and cardiac function. Thirty ED patients and 20 healthy male subjects (mean ages: 48.7 +/- 11.7 and 48.3 +/- 8.7 years, respectively) were enrolled. Endothelium functions were assessed by applanation tonometry. Aortic stiffness and cardiac function were evaluated by transthoracic echocardiography. Pulse pressure was greater in the ED group (P < 0.05), whereas aortic strain and aortic distensibility were significantly lower (P < 0.001). Treatment with tadalafil reduced pulse pressure (P = 0.0179), systolic blood pressure (P = 0.001) and diastolic blood pressure (P = 0.054) and increased aortic distensibility (P = 0.001) and aortic strain (P = 0.003) in the ED group. Tadalafil administration also increased large artery and small artery elasticity indices that were reduced in the ED group at baseline (P = 0.02 and 0.003, respectively). Systemic vascular disease and compromised left ventricular diastolic function (LVDF) were present in ED patients with no known atherosclerotic risk factors and cardiac diseases. Tadalafil positively affected arterial stiffness and LVDF.
URI: https://doi.org/10.1038/ijir.2016.47
https://www.nature.com/articles/ijir201647
1476-5489
http://hdl.handle.net/11452/30516
ISSN: 0955-9930
Appears in Collections:Scopus
Web of Science

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