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http://hdl.handle.net/11452/30516
Başlık: | Evaluation of arterial stiffness and cardiac function in patients with vascular erectile dysfunction: Acute effects of phosphodiesterase-5 inhibitor tadalafil |
Yazarlar: | Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı. 0000-0002-8974-8837 0000-0001-8404-8252 Özdabakoǧlu, Osman Güllülü, Sümeyye Saǧ, Saim Şentürk, T. Kılıçarslan, Hakan Tütüncü, Ahmet S. Keçebaş, Mesut Baran, İbrahim Aydınlar, Ali AAI-6632-2021 AAW-9185-2020 25221805700 57204660708 12140008100 8342098300 56007473800 7004229025 36198369900 35572557400 6603131517 |
Anahtar kelimeler: | Urology & nephrology Ischemic-heart-disease Pulse-wave velocity Pressure Men |
Yayın Tarihi: | 3-Eki-2016 |
Yayıncı: | Springernature |
Atıf: | Özdabakoğlu, O. vd. (2017). ''Evaluation of arterial stiffness and cardiac function in patients with vascular erectile dysfunction: Acute effects of phosphodiesterase-5 inhibitor tadalafil''. International Journal of Impotence Research, 29(3), 96-100. |
Özet: | This study aimed to detect endothelial dysfunction in erectile dysfunction (ED) patients free from cardiovascular diseases or atherosclerotic risk factors and to evaluate acute effects of phosphodiesterase-5 inhibitor tadalafil on endothelial dysfunction and cardiac function. Thirty ED patients and 20 healthy male subjects (mean ages: 48.7 +/- 11.7 and 48.3 +/- 8.7 years, respectively) were enrolled. Endothelium functions were assessed by applanation tonometry. Aortic stiffness and cardiac function were evaluated by transthoracic echocardiography. Pulse pressure was greater in the ED group (P < 0.05), whereas aortic strain and aortic distensibility were significantly lower (P < 0.001). Treatment with tadalafil reduced pulse pressure (P = 0.0179), systolic blood pressure (P = 0.001) and diastolic blood pressure (P = 0.054) and increased aortic distensibility (P = 0.001) and aortic strain (P = 0.003) in the ED group. Tadalafil administration also increased large artery and small artery elasticity indices that were reduced in the ED group at baseline (P = 0.02 and 0.003, respectively). Systemic vascular disease and compromised left ventricular diastolic function (LVDF) were present in ED patients with no known atherosclerotic risk factors and cardiac diseases. Tadalafil positively affected arterial stiffness and LVDF. |
URI: | https://doi.org/10.1038/ijir.2016.47 https://www.nature.com/articles/ijir201647 1476-5489 http://hdl.handle.net/11452/30516 |
ISSN: | 0955-9930 |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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