Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/30737
Title: Association of b7-h4 gene polymorphisms in urothelial bladder cancer
Authors: Özgöz, Asuman
Şamlı, Murat
Şahin, Ahmet
İnce, Ümit
Sağlıcan, Yeşim
Uludağ Üniversitesi/Veteriner Fakültesi/Genetik Anabilim Dalı.
0000-0002-8015-9032
Dinçel, Deniz
Balcı, Faruk
Şamlı, Hale
AAH-6192-2021
AAH-6488-2021
56607385000
16062981700
6507670789
Keywords: General & internal medicine
Bladder cancer
Polymorphism
B7-H4 gene
T-cell-activation
B7 family-mem
Berbreast-cancer
Immunity
Expression
Costimulation
Molecules
Ligands
Issue Date: 7-Jul-2016
Publisher: TÜBİTAK
Citation: Özgöz, A. vd. (2017). ''Association of b7-h4 gene polymorphisms in urothelial bladder cancer''. Turkish Journal of Medical Sciences, 47(2), 443-446.
Abstract: Background/aim: We aimed to study polymorphisms of the B7-H4 gene in order to evaluate a possible association in urothelial carcinoma, as it is highly expressed in cancer tissues. Materials and methods: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer. Results: We detected that the rs10754339 polymorphism was more frequent in the cancer patients when compared with the control group (P < 0.05). Only the rs3738414 polymorphism showed a statistically significant difference in frequency between pathologic diagnostic groups. Conclusion: The rs10754339 AA genotype distribution was found to have a higher frequency whereas the rs3738414 AG genotype distribution was lower in the bladder cancer group (P < 0.05). None of the genotype distributions showed a significant difference from the control group for the rs10801935 polymorphism. We conclude that B7-H4 has the potential to be a useful prognostic marker in urothelial carcinoma.
URI: https://doi.org/10.3906/sag-1603-54
1303-6165
https://journals.tubitak.gov.tr/medical/vol47/iss2/12/
http://hdl.handle.net/11452/30737
ISSN: 1300-0144
Appears in Collections:Scopus
TrDizin
Web of Science

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