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Başlık: Effect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in rats
Yazarlar: İnan, Sevda
Akgül, Mustafa Barış
Bağdaş, Deniz
Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Gıda Mühendisliği Bölümü.
Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.
Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.
Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.
Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Endokrinolojisi Anabilim Dalı.
0000-0003-3954-0058
0000-0002-6947-2167
0000-0003-0441-1707
0000-0003-1840-1825
0000-0002-9732-5340
0000-0002-9562-4195
0000-0002-2593-7196
0000-0002-7346-7440
0000-0002-5322-5508
0000-0002-2382-290X
0000-0001-5871-8769
0000-0001-6128-7453
0000-0002-1951-7937
Sinir-Özcan, Gülşah
Suna, Senem
Tamer, Canan Ece
Sönmez, Gürsel
Evrensel, Türkkan
Kaya, Ekrem
Sarandöl, Emre
Dündar, Halit Ziya
Tarım, Ömer Faruk
Ercan, İlker
Sığırlı, Deniz
İncedayı, Bige
Çopur, Ömer Utku
AAG-8277-2021
ABE-1716-2020
AAQ-8178-2020
AAJ-1027-2021
AAG-7319-2021
AAG-8503-2021
AAG-8336-2021
AAA-7472-2021
ABF-2367-2020
57194441710
55512747500
8228159500
55167435000
6603942124
7004568109
55943324800
55453773300
6701427186
Anahtar kelimeler: Normal dietary consumption
Cancer-risk
Insulin-resistance
Pooled analysis
Intraepithelial neoplasia
Glycemic load
Body-weight
Glucose
Obesity
Sugar
Oncology
Nutrition & dietetics
Yayın Tarihi: 12-May-2020
Yayıncı: Routledge Journals
Atıf: Sinir-Özcan, G. vd. (2021). "Effect of high fructose corn sirup on pancreatic ductal adenocarcinoma induced by dimethyl benzantracene (DMBA) in rats". Nutrition and Cancer, 73(2), 339-349.
Özet: Increased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals withad libitumaccess to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats.
URI: https://doi.org/10.1080/01635581.2020.1770811
https://www.tandfonline.com/doi/full/10.1080/01635581.2020.1770811
http://hdl.handle.net/11452/30791
ISSN: 0163-5581
1532-7914
Koleksiyonlarda Görünür:PubMed
Scopus
Web of Science

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