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http://hdl.handle.net/11452/30939
Başlık: | Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats |
Yazarlar: | Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. 0000-0002-9790-7295 Özmerdiven, Gökhun Vuruşkan, Berna Aytaç Kaygısız, Onur Vuruşkan, Hakan AAH-9746-2021 AAM-9726-2020 L-9439-2019 56497875900 56527372000 16637252400 6507328150 |
Anahtar kelimeler: | General & internal medicine Diltiazem Ischemia-reperfusion injury Heat shock protein Shock wave lithotripsy Renal tubules Tadalafil Renal ischemia-reperfusion Ischemia/reperfusion injury Tubular dysfunction Lithotripsy Nifedipine Calcium Allopurinol Mechanisms Verapamil Pig |
Yayın Tarihi: | 21-Ara-2016 |
Yayıncı: | Aepress Sro |
Atıf: | Özmerdiven, G. vd. (2017). ''Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats''. Bratislava Medical Journal, 118(4), 228-232. |
Özet: | BACKGROUND: We aimed to compare the protective effects of tadalafil and diltiazem on renal histology after ischemia and reperfusion injury in a rat model of shock wave lithotripsy. METHODS: A total of 40 adult, male Sprague-Dawley rats were randomized into four groups as follows; control group (group C), group S (SWL + nephrectomy), group T (SWL + tadalafil given before nephrectomy) and group D (SWL + diltiazem given before nephrectomy). Both kidneys were evaluated regarding tubular damage, peritubular fibrosis and heat shock protein-70 (HSP-70) immune-expression of glomeruli, cortical and medullar collector tubules on light microscopy. RESULTS: HSP-70 levels of cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group T compared with group S. Similarly, HSP-70 immunostaining levels on cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group D compared with group S. No significant difference was detected between group D and group T for all parameters. CONCLUSION: As a result, shock waves induced renal cell damage due to increment of HSP-70 levels, morphological irregularity in tubules and increased peritubular fibrosis. Tadalafil and diltiazem had beneficial effects in decreasing renal tissue damage which was caused by SWL |
URI: | https://doi.org/10.4149/BLL_2017_045 1336-0345 http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=5189&category_id=135&option=com_virtuemart&vmcchk=1&Itemid=1 http://hdl.handle.net/11452/30939 |
ISSN: | 0006-9248 |
Koleksiyonlarda Görünür: | Scopus Web of Science |
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