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Başlık: Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
0000-0002-9790-7295
Özmerdiven, Gökhun
Vuruşkan, Berna Aytaç
Kaygısız, Onur
Vuruşkan, Hakan
AAH-9746-2021
AAM-9726-2020
L-9439-2019
56497875900
56527372000
16637252400
6507328150
Anahtar kelimeler: General & internal medicine
Diltiazem
Ischemia-reperfusion injury
Heat shock protein
Shock wave lithotripsy
Renal tubules
Tadalafil
Renal ischemia-reperfusion
Ischemia/reperfusion injury
Tubular dysfunction
Lithotripsy
Nifedipine
Calcium
Allopurinol
Mechanisms
Verapamil
Pig
Yayın Tarihi: 21-Ara-2016
Yayıncı: Aepress Sro
Atıf: Özmerdiven, G. vd. (2017). ''Protective effects of diltiazem and tadalafil on shock wave-induced kidney injury in rats''. Bratislava Medical Journal, 118(4), 228-232.
Özet: BACKGROUND: We aimed to compare the protective effects of tadalafil and diltiazem on renal histology after ischemia and reperfusion injury in a rat model of shock wave lithotripsy. METHODS: A total of 40 adult, male Sprague-Dawley rats were randomized into four groups as follows; control group (group C), group S (SWL + nephrectomy), group T (SWL + tadalafil given before nephrectomy) and group D (SWL + diltiazem given before nephrectomy). Both kidneys were evaluated regarding tubular damage, peritubular fibrosis and heat shock protein-70 (HSP-70) immune-expression of glomeruli, cortical and medullar collector tubules on light microscopy. RESULTS: HSP-70 levels of cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group T compared with group S. Similarly, HSP-70 immunostaining levels on cortical and medullar collector tubules, tubular damage and peritubular fibrosis scores were decreased in group D compared with group S. No significant difference was detected between group D and group T for all parameters. CONCLUSION: As a result, shock waves induced renal cell damage due to increment of HSP-70 levels, morphological irregularity in tubules and increased peritubular fibrosis. Tadalafil and diltiazem had beneficial effects in decreasing renal tissue damage which was caused by SWL
URI: https://doi.org/10.4149/BLL_2017_045
1336-0345
http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=5189&category_id=135&option=com_virtuemart&vmcchk=1&Itemid=1
http://hdl.handle.net/11452/30939
ISSN: 0006-9248
Koleksiyonlarda Görünür:Scopus
Web of Science

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