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Başlık: The relationship between maternal and umbilical cord adropin levels with the presence and severity of preeclampsia
Yazarlar: Çakmak, Burcu Dinçgez
Dündar, Betül
Açıkgöz, Abdullah Serdar
Özgen, Gülten
Çift, Tayfur
Altekin, Yasin
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
0000-0003-1550-639X
Ahmedian, Robab
AAE-5602-2019
57196020500
Anahtar kelimeler: Obstetrics & gynecology
Pediatrics
Adropin
Maternal
Preeclampsia
Severity
Umbilical cord blood
Gestational diabetes-mellitus
Nitric-oxide
Endothelial function
Plasma adropin
Adenosine
Pregnancies
Dysfunction
Expression
Growth
Yayın Tarihi: 11-May-2017
Yayıncı: Walter de Gruyter Gmbh
Atıf: Çakmak, B. D. vd. (2017). ''The relationship between maternal and umbilical cord adropin levels with the presence and severity of preeclampsia''. Journal of Perinatal Medicine, 45(7), 879-885.
Özet: Aim: To investigate both maternal and umbilical cord adropin levels in patients with preeclampsia and the possible relations with its severity and perinatal outcomes. Materials and methods: In this study, a total of 38 preeclamptic and 40 age- matched healthy pregnant women between January and June 2016 were included. Serum and cord adropin levels were measured using an enzymelinked immunosorbent assay (ELISA). Results: The maternal and umbilical cord adropin levels were significantly lower in the preeclamptic group compared to controls [71.19 +/- 22.21 vs. 100.76 +/- 27.02 ng/L and 92.39 (59.77:129.89) vs. 106.20 (74.42: 208.02) ng/L, P < 0.001, respectively]. While maternal adropin levels were significantly lower in the severe preeclampsia group as compared to the mild preeclamptic group [66.45 (21.49:98.02) vs. 76.17 (58.06:109.58), P = 0.007], umbilical cord adropin levels did not differ between each group [91.32 (59.77:113.34) vs. 92.87 (63.12:129.89), P = 0.750]. Maternal adropin level was negatively correlated with systolic and diastolic blood pressures (r = - 0.60, P < 0.001 and r = - 0.58, P < 0.001, respectively) and positively correlated with platelet count (r = 0.27, P = 0.016). Moreover, umbilical cord adropin levels were weakly correlated with gestational age at delivery (r = 0.28, P = 0.012) and birth weight (r = 0.28, P = 0.014). Conclusion: The present study is the first to demonstrate a significant association between maternal and umbilical adropin levels and the presence and severity of preeclampsia. Adropin might be a useful parameter for predicting the presence and severity of preeclampsia.
URI: https://doi.org/10.1515/jpm-2017-0053
https://www.degruyter.com/document/doi/10.1515/jpm-2017-0053/html
http://hdl.handle.net/11452/31098
ISSN: 0300-5577
1619-3997
Koleksiyonlarda Görünür:Scopus
Web of Science

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