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Başlık: Assessing the impact of insulin glargine and detemir treatment to serum total IGF1 levels in the insulin-naive type 2 diabetic patients
Yazarlar: Dizdar, Oğuzhan Sıtkı
Koca, Nizameddin
Aydın, Taner
Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
0000-0002-2593-7196
Cander, Soner
Gül, Özen Öz
Sarandöl, Emre
Ersoy, Canan
AAI-1005-2021
ABE-1716-2020
AAH-8861-2021
25027068600
26040787100
55943324800
6701485882
Anahtar kelimeler: Research & experimental medicine
Insulin analogs
Detemir
Glargine
IGF1
Diabetescancer
Growth-factor-I
Analogs
Cancer
Receptor
Binding
Malignancies
Metabolites
Population
Metformin
Therapy
Yayın Tarihi: Haz-2017
Yayıncı: Mary Ann Liebert
Atıf: Cander, S. vd. (2017). ''Assessing the impact of insulin glargine and detemir treatment to serum total IGF1 levels in the insulin-naive type 2 diabetic patients''. Metabolic Syndrome and Related Disorders, 15(5), 220-225.
Özet: Aim: The mitogenic potential of analog insulins due to their different insulin-like growth factor-1 (IGF1) receptor affinity is a situation that causes concern related to cancer risk. We aimed to examine the changes in the serum IGF1 levels formed by insulin glargine and detemir in the insulin-naive type 2 diabetic patients. Methods: The serum total IGF1 levels of the 62 insulin-naive type 2 diabetic patients were studied before and after 12 weeks of the started treatment with basal insulin analogs. Twenty-two and twenty patients (Group I and II) using the single-dose and double-dose insulin detemir and twenty patients (Group III) using insulin glargine were evaluated. Results: In Group I and Group II, the average 8.5% and 0.1% increases and in the Group III, 6.5% decreases were determined in the IGF1 values. The IGF1 changes were significant in the men but not in the women. Conclusion: In our study, it was determined that the insulin glargine depressed the serum IGF1 levels much more when compared to the insulin detemir. This result can be evaluated as the in vivo reflection of the in vitro findings related to the fact that the IGF1 receptor affinity of the glargine is higher.
URI: https://doi.org/10.1089/met.2017.0005
https://www.liebertpub.com/doi/10.1089/met.2017.0005
http://hdl.handle.net/11452/31306
ISSN: 1540-4196
1557-8518
Koleksiyonlarda Görünür:Scopus
Web of Science

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