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Başlık: Retrospective analysis of clinicopathological features of solid pseudopapillary neoplasm of the pancreas
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.
0000-0002-7346-7440
Uğraş, Nesrin
Yerci, Ömer
Coşkun, Sinem Kantarcıoğlu
Ocakoğlu, Gökhan
Sarkut, Pınar
Dündar, Halit Ziya
AAH-2716-2021
AAH-5180-2021
55386535600
6603810549
57212620333
15832295800
55806454400
55453773300
Anahtar kelimeler: Research & experimental medicine
Clear cells
Clinicopathological findings
Pancreas
Solid pseudopapillary neoplasm
Clear-cell variant
Pathological features
Clinical-features
Tumor
Yayın Tarihi: 6-May-2016
Yayıncı: Wiley
Atıf: Uğraş, N. vd. (2016). "Retrospective analysis of clinicopathological features of solid pseudopapillary neoplasm of the pancreas". Kaohsiung Journal of Medical Sciences, 32(7), 356-361.
Özet: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm that accounts for 2-3% of all primary pancreatic neoplasms. This study aimed to characterize clinicopathological features associated with SPNs and to retrospectively evaluate the relationship of these features with predictive parameters associated with aggressive behavior. We reviewed 16 cases of SPN of the pancreas that had been diagnosed between 2005 and 2014 at our pathology department. A total of 16 cases, 15 female and one male, were evaluated in this study. The patient age ranged from 13 years to 63 years with a median of 35.70 years. The mean tumor diameter ranged from 2 cm to 18 cm with a mean diameter of 5.90 cm. We identified a significant association between the presence of clear cells and perineural invasion (p = 0.019), which was considered to be a predictive factor for aggressive behavior. Other features (i.e., localization, nuclear grooves, central hyalinization, myxoid stroma, eosinophilic bodies, foamy histiocyte aggregates, multinucleated cells, and calcification) were not significantly associated with predictive factors for aggressive behavior. One patient died as a result of a pancreatic fistula that developed as a postoperative complication. The remaining 15 patients are alive and have not demonstrated any signs of recurrence or metastasis. The current study suggested that the presence of clear cells might serve as a possible prognostic indicator of perineural invasion, which is a predictive parameter associated with aggressive behavior in SPN. Copyright
URI: https://doi.org/10.1016/j.kjms.2016.05.009
https://onlinelibrary.wiley.com/doi/full/10.1016/j.kjms.2016.05.009
http://hdl.handle.net/11452/32151
ISSN: 1607-551X
Koleksiyonlarda Görünür:Scopus
Web of Science

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