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Başlık: Associations between polymorphisms of IL-17F and IL-17A genes with disease activity and clinical outcome of Ankylosing Spondylitis
Yazarlar: İnal, Erkol Esra
Eroğlu, Selma
Solak, Özlem
Görükmez, Özlem
Uludağ Üniversitesi/Tıp Fakültesi//Tıbbi Genetik Anabilim Dalı.
Sağ, Özemri
Görukmez, Orhan
Yakut, Tahsin
AFZ-0764-2022
56681045900
56879109500
6602802424
Anahtar kelimeler: Rheumatology
Ankylosing spondylitis
7383 A/G
7488 A/G
G197A
IL-17 gene
Interleukin-17f genes
T-cell
Susceptibility
IL17F
Reliability
Severity
T(h)17
Erap1
IL23R
Yayın Tarihi: 2016
Yayıncı: Publisaude-Edicoes Medicas
Atıf: İnal, E. vd. (2016). "Associations between polymorphisms of IL-17F and IL-17A genes with disease activity and clinical outcome of Ankylosing Spondylitis". Acta Reumatologica Portuguesa, 41(3), 232-239.
Özet: Aims: In this study, we aimed to investigate the associations between the 7383A/G and 7488A/G polymorphisms of the interleukin (IL)-17F gene and the G197A polymorphism of the IL-17A gene with disease activity and clinical outcomes in Turkish patients with ankylosing spondylitis (AS). Methods: The study included 101 AS patients and 106 healthy controls. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, in addition to scores of the Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Metrology Index and Bath Ankylosing Spondylitis Functional Index (BASFI) of the patients, were recorded. The frequencies of genotypes 7383A/G and 7488A/G of the IL-17F and G197A of IL-17A genes and alleles were compared between the patients and healthy controls. Results: There were significant differences in the allele frequencies and genotype distribution of IL-17F 7488A/G. There were also significant differences in the CRP levels and BASFI scores of patients due to the genotype distribution of the IL-17F 7488A/G polymorphism (p=0.029, 0.045, respectively). Conclusions: This study suggests that the IL-17F 7488A/G polymorphism may be associated with susceptibility to AS, disease activity and functional status in Turkish patients. Further studies with larger numbers of AS patients, with a long-term follow-up, are needed to elucidate the observed relations.
URI: http://hdl.handle.net/11452/32383
ISSN: 0303-464X
Koleksiyonlarda Görünür:Scopus
Web of Science

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