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Başlık: Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage
Yazarlar: Millington, William R.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı.
0000-0001-6261-4233
Göktalay, Gökhan
AAH-1448-2021
6508023759
Anahtar kelimeler: Neurosciences & neurology
Hemorrhagic shock
Lateral hypothalamus
Ventromedial hypothalamus
Arcuate nucleus
Fos immunoreactivity
Ventrolateral periaqueductal gray
Nucleus-tractus-solitarius
Delta-opioid receptors
Vulgaris-leukoagglutinin
Cardiovascular-responses
Anterior hypothalamus
Efferent connections
L-glutamate
Brain-stem
Excitatory projections
Hemorrhage
Yayın Tarihi: 27-Şub-2016
Yayıncı: Elsevier
Atıf: Göktalay, G. ve Millington, W. R. (2016). "Hypovolemic hemorrhage induces Fos expression in the rat hypothalamus: Evidence for involvement of the lateral hypothalamus in the decompensatory phase of hemorrhage". Neuroscience, 322, 464-478.
Özet: This study tested the hypothesis that the hypothalamus participates in the decompensatory phase of hemorrhage by measuring Fos immunoreactivity and by inhibiting neuronal activity in selected hypothalamic nuclei with lidocaine or cobalt chloride. Previously, we reported that inactivation of the arcuate nucleus inhibited, but did not fully prevent, the fall in arterial pressure evoked by hypotensive hemorrhage. Here, we report that hemorrhage (2.2 ml/100 g body weight over 20 min) induced Fos expression in a high percentage of cells in the paraventricular, supraoptic and arcuate nuclei of the hypothalamus as shown previously. Lower densities of Fos immunoreactive cells were also found in the medial preoptic area (mPOA), anterior hypothalamus, lateral hypothalamus (LH), dorsomedial hypothalamus, ventromedial hypothalamus (VMH) and posterior hypothalamus. Bilateral injection of lidocaine (2%; 0.1 mu l or 0.3 mu l) or cobalt chloride (5 mM; 0.3 mu l) into the tuberal portion of the LH immediately before hemorrhage was initiated reduced the magnitude of hemorrhagic hypotension and bradycardia significantly. Lidocaine injection into the VMH also attenuated the fall in arterial pressure and heart rate evoked by hemorrhage although inactivation of the mPOA or rostral LH was ineffective. These findings indicate that hemorrhage activates neurons throughout much of the hypothalamus and that a relatively broad area of the hypothalamus, extending from the arcuate nucleus laterally through the caudal VMH and tuberal LH, plays an important role in the decompensatory phase of hemorrhage.
URI: https://doi.org/10.1016/j.neuroscience.2016.02.068
https://www.sciencedirect.com/science/article/pii/S0306452216002177
http://hdl.handle.net/11452/32390
ISSN: 0306-4522
1873-7544
Koleksiyonlarda Görünür:Scopus
Web of Science

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