Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/32973
Title: A multicenter report of biologic agents for the treatment of secondary amyloidosis in Turkish rheumatoid arthritis and ankylosing spondylitis patients
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.
Pehlivan, Yavuz
Öksüz, Mustafa Ferhat
AAG-8227-2021
57220381538
56016440100
Keywords: Rheumatology
Secondary amyloidosis
Rheumatoid arthritis
Ankylosing spondylitis
Biologic therapy
Anti-TNF
AA amyloidosis
Etanercept
Efficacy
Criteria
Tocilizumab
Prevalence
Infliximab
Resolution
Therapy
Safety
Issue Date: 16-May-2016
Publisher: Springer
Citation: Pamuk, Ö. N. vd. (2016). "A multicenter report of biologic agents for the treatment of secondary amyloidosis in Turkish rheumatoid arthritis and ankylosing spondylitis patients". Rheumatology International, 36(7), 945-953.
Abstract: In this multicenter, retrospective study, we evaluated the efficacy and safety of biologic therapies, including anti-TNFs, in secondary (AA) amyloidosis patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA). In addition, the frequency of secondary amyloidosis in RA and AS patients in a single center was estimated. Fifty-one AS (39M, 12F, mean age: 46.7) and 30 RA patients (11M, 19F, mean age: 51.7) with AA amyloidosis from 16 different centers in Turkey were included. Clinical and demographical features of patients were obtained from medical charts. A composite response index (CRI) to biologic therapy-based on creatinine level, proteinuria and disease activity-was used to evaluate the efficacy of treatment. The mean annual incidence of AA amyloidosis in RA and AS patients was 0.23 and 0.42/1000 patients/year, respectively. The point prevalence in RA and AS groups was 4.59 and 7.58/1000, respectively. In RA group with AA amyloidosis, effective response was obtained in 52.2 % of patients according to CRI. RA patients with RF positivity and more initial disease activity tended to have higher response rates to therapy (p values, 0.069 and 0.056). After biologic therapy (median 17 months), two RA patients died and two developed tuberculosis. In AS group, 45.7 % of patients fulfilled the criteria of good response according to CRI. AS patients with higher CRP levels at the time of AA diagnosis and at the beginning of anti-TNF therapy had higher response rates (p values, 0.011 and 0.017). During follow-up after anti-TNF therapy (median 38 months), one patient died and tuberculosis developed in two patients. Biologic therapy seems to be effective in at least half of RA and AS patients with AA amyloidosis. Tuberculosis was the most important safety concern.
Description: Çalışmada 24 yazar bulunmaktadır. Bu yazarlardan sadece Bursa Uludağ Üniversitesi mensuplarının girişleri yapılmıştır.
URI: https://doi.org/10.1007/s00296-016-3500-9
https://link.springer.com/article/10.1007/s00296-016-3500-9
http://hdl.handle.net/11452/32973
ISSN: 0172-8172
1437-160X
Appears in Collections:Scopus
Web of Science

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