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Başlık: Favourable outcome of de novo advanced phases of childhood chronic myeloid leukaemia
Yazarlar: Millot, Frederic
Maledon, Natacha
Guilhot, Joelle
Kalwak, Krzysztof
Suttorp, Meinolf
Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri/Çocuk Sağlığı Ve Hastalıkları Bölümü.
Güneş, Adalet Meral
24072843300
Anahtar kelimeler: Oncology
Chronic myeloid leukaemia
Imatinib
Tyrosine kinase inhibitors
Stem cell transplantation
Children
Chronic myelogenous leukemia
Tyrosine kinase inhibitors
Lymphoid blast crisis
International registry
Prognostic-factors
Interphase-fish
Cml patients
Recommendations
Children
Survival
Yayın Tarihi: Tem-2019
Yayıncı: Elsevier
Atıf: Millot, F. vd. (2019). ''Favourable outcome of de novo advanced phases of childhood chronic myeloid leukaemia''. European Journal of Cancer, 115, 17-23.
Özet: Background: Chronic myeloid leukaemia (CML) is very rare in children. The aim of the study is to report the experience within the I-CML-Ped study in children and adolescents presenting at diagnosis with advanced phase disease and to describe their characteristics and outcomes. Methods: Of 479 children and adolescents enrolled in the international registry for childhood chronic myeloid leukaemia (I-CML-Ped Study; www.clinicaltrials.gov NCT01281735), 36 children (7.5%) presented at initial diagnosis with CML in advanced phase according to the European Leukemia Net criteria. Results: Nineteen (4%) patients were diagnosed in accelerated phase (CML-AP), and among the 17 patients (3.5%) diagnosed in blastic phase (CML-BP), 70% presented with lymphoid immunophenotype. Initial treatment of CML-AP/CML-BP consisted of tyrosine kinase inhibitors (TKIs) with or without chemotherapy, leading to complete haematologic response in 33 of 36 (92%) patients. Seventeen patients proceeded to haematopoietic stem cell transplantation. At the last follow-up, 18 of 19 patients with de novo CML-AP are alive in at least major molecular response (MMR) (n = 16), in progression (n = 1) or in molecular relapse (n = 1) and 13 of 17 patients with de novo CML-BP are alive in at least MMR. Five-year overall survival rates are 94% (95% confidence interval [CI]: 66%-99%) and 74% (95% CI: 44%-89%) for patients diagnosed in CML-AP and CML-BP, respectively. Conclusion: Children with advanced phase at diagnosis of CML seem to have a better survival rate than that reported for advanced phases evolving under TKI treatment.
URI: https://doi.org/10.1016/j.ejca.2019.03.020
https://www.sciencedirect.com/science/article/pii/S0959804919302229
http://hdl.handle.net/11452/33036
ISSN: 0959-8049
1879-0852
Koleksiyonlarda Görünür:Scopus
Web of Science

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