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Başlık: Polymorphisms of glutathione-s-transferase M1, T1, and P1 genes in endometrial carcinoma
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Bölümü.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.
0000-0002-3894-1231
Özerkan, Kemal
Atalay, Mehmet Aral
Yakut, Tahsin
Doster, Y.
Yılmaz, Emel
Karkucak, Mutlu
AAH-9791-2021
ABI-5648-2022
6603345841
53863297800
6602802424
55623210600
22037135100
35388323500
Anahtar kelimeler: Oncology
Obstetrics & gynecology
Polymorphism
Gene
Glutathione-s-transferase
Adenocarcinoma
Carcinoma
Endometrium
Lung-cancer
Susceptibility
Pi
Assosciation
Gst
Bladder
Population
Maetabolism
Genotypes
Family
Yayın Tarihi: 2013
Yayıncı: IMR Press
Atıf: Özerkan, K. vd. (2013). “Polymorphisms of glutathione-s-transferase M1, T1, and P1 genes in endometrial carcinoma”. European Journal of Gynaecological Oncology, 34(1), 42-47.
Özet: Objective: To investigate the polymorphism rates and possible roles of glutathione-s-transferase M1, T1, and P1 gene polymotphisms in the predisposition to endometrial cancer in Caucasian women. Materials and Methods: Serum samples and medical records were collected from 53 Caucasian women with newly diagnosed endometrial cancer and 67 women of the same race without any known history of cancer. Multiplex polymerase chain reaction (PCR) analysis was used to assess glutathione-s-transferase M1 (GSTM1) and T1 gene polymorphisms. Polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method was used in salvage of GSTP1 gene polymorphism. Results: Frequencies of GSTM1 and GSTT1 null genotypes were not significantly different between the controls and patients with endometrial cancer (56.7% vs 52.8%, p = 0.671; 32.8% vs 26.4%, p = 0.574, respectively). The authors were not able to demonstrate any association between neither GSTP1 genotypes nor allele frequencies and endometrial carcinoma in the population studied (p = 0.310, p = 0.318, respectively). Moreover, no significant association could be demonstrated with GSTM1 and GSTT1 polymorphisms and clinical stages of endometrial cancer. Nevertheless, there was a significant difference between the frequencies of GSTP1 AA and GG genotypes in relation to Stage I disease when compared with advanced stages of endometrial carcinoma (p = 0.03). In addition, no association was found between polymorphisms of GST suspergene family and non-endometrioid type endometrial carcinomas. Conclusion: These results suggest that GSTT1, GSTM1, and GSTP1 polymorphisms are not associated with endometrial cancer in the Caucasian population.
URI: http://hdl.handle.net/11452/33098
ISSN: 0392-2936
Koleksiyonlarda Görünür:Scopus
Web of Science

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