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http://hdl.handle.net/11452/33469| Title: | The matter of clinical sequencing for familial breast cancer: The route from Sanger to next generation |
| Authors: | Eskiler, Gamze Güney Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. 0000-0002-3316-316X 0000-0002-1619-6680 0000-0002-3820-424X 0000-0002-3316-316X 0000-0001-7904-883X Eryılmaz, Işıl Ezgi Çeçener, Gülşah Egeli, Ünal Tunca, Berrin GWV-3548-2022 ABI-6078-2020 AAP-9988-2020 AAH-1656-2021 AAH-1420-2021 57189380840 6508156530 55665145000 6602965754 |
| Keywords: | Computer science Engineering Medical informatics Genes Risk analysis Risk assessment Familial breast cancer Next generation sequencing Early-onset Inherited mutations Dna-repair Risk Brca1 Association Variants Palb2 Breast cancer Genes mutation Genetic predisposition Knowledge gaps Next-generation sequencing Risk determination Sanger sequencing Sequence analysis Diseases |
| Issue Date: | 2017 |
| Publisher: | IEEE |
| Citation: | Eryılmaz, I. E. vd. (2017). ''The matter of clinical sequencing for familial breast cancer: The route from Sanger to next generation''. E-Health and Bioengineering Conference, 2017 IEEE Internatıonal conference on E-health and bioengineerıng conference (EHB), 181-184. |
| Abstract: | We mentioned the importance of clinical sequence analysis in risk determination, diagnostic and therapeutic process of familial breast cancer and we also summarized next generation sequencing applications in this cancer type. In conclusion, BRCA1/2 genes mutations are associated with an increasing the risk of particularly familial breast cancer. However, sequencing of moderate penetrance genes and/or whole exome could also fill large knowledge gaps in explaining genetic predisposition of breast cancer. |
| Description: | Bu çalışma, 22-24 Haziran 2017 tarihlerinde Sinaia[Romanya]’da düzenlenen 6. IEEE International Conference on E-Health and Bioengineering (EHB) Kongresi‘nde bildiri olarak sunulmuştur. |
| URI: | http://hdl.handle.net/11452/33469 |
| ISBN: | 978-1-5386-0358-1 |
| ISSN: | 2575-5137 2575-5145 |
| Appears in Collections: | Scopus Web of Science |
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