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Başlık: Comparison of efficacy and safety of once- versus twice-daily insulin detemir added on to oral antidiabetics in insulin-naive type 2 diabetes patients: 24-Week, crossover, treat to target trial in a single center
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.
0000-0001-5082-9894
Cander, Soner
Dizdar, Oğuzhan Sıtkı
Öz Gül, Özen
Güçlü, Metin
Ünal, Oǧuz Kaan
Tuncel, Ercan
Ertürk, Erdinç
İmamoğlu, Şazi
Ersoy, Canan Özyardımcı
AAJ-6536-2021
AAH-8861-2021
AAI-1005-2021
ABI-4847-2020
25027068600
55202193000
26040787100
15073842600
55042241400
7006929833
7005488796
6602297533
6701485882
Anahtar kelimeler: Detemir
Type 2 diabetes
HbA1c
Once daily
Hypoglycemia
Insulin dose
Improves glycemic control
Variability
Nph insulin
Analog
Weight-gain
Therapy
Double-blind
Hypoglycemia
Glargine
Predictive(tm)
Endocrinology & metabolism
General & internal medicine
Yayın Tarihi: 18-Oca-2014
Yayıncı: Elsevier
Atıf: Cander, S. vd. (2014). "Comparison of efficacy and safety of once- versus twice-daily insulin detemir added on to oral antidiabetics in insulin-naive type 2 diabetes patients: 24-Week, crossover, treat to target trial in a single center". Primary Care Diabetes, 8(3), 256-264.
Özet: Aim: To compare once- versus twice-daily insulin detemir added on OADS therapy in insulin-naive type 2 diabetes patients in terms of efficacy and safety. Methods: An open-label study performed at a single center, comprised a randomized, crossover 24 week with insulin-naive type 2 diabetes patients. Insulin detemir was initiated with mean 0.12 U/kg in all patients (Group I once-daily, Group II twice-daily) and titrated for 24 week. Results: A total of 50 patients completed the study (Group I n:25, Group II n:25). With use of once- and twice-daily insulin, HbA1c values were decreased by 1.8% (+/- 2.0) and 1.5% (+/- 1.4) within the first 12 weeks (p<0.01), whereas increased by 0.21% (+/- 0.7) and 0.14% (+/- 0.8) in the second 12 weeks (p>0.05). The increases in the insulin doses were found as 0.22 U/kg and 0.35 U/kg with once- and twice-daily insulin use, respectively (p:0.04). Although minor hypoglycemic events were similar in both groups in the first 12 weeks, 2-fold increase was found in the patients shifting from once- to twice-daily dose. Within the first and second periods, the body weight of the patients was observed an increase of 0.4 and 1.6 kg with once-daily dose, whereas a decrease of 0.1 and 2.1 kg in the twice-daily dose, in the same period. Conclusion: Once-daily use of insulin detemir up to 0.4 U/kg was found to have similar efficacy and safety as twice-daily use. Twice dose use of insulin did not provide a prominent glycemic control advantage on 1.5-fold higher use of insulin.
URI: https://doi.org/10.1016/j.pcd.2014.01.010
https://www.sciencedirect.com/science/article/pii/S1751991814000114
http://hdl.handle.net/11452/33853
ISSN: 1751-9918
1878-0210
Koleksiyonlarda Görünür:Scopus
Web of Science

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