Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/33890
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dc.date.accessioned2023-09-19T08:17:18Z-
dc.date.available2023-09-19T08:17:18Z-
dc.date.issued2014-07-17-
dc.identifier.citationÜnal, O. K. vd. (2014). "Investigation of genotoxicity in acromegaly from peripheral blood lymphocyte cultures using a micronucleus assay". Journal of Clinical Endocrinology and Metabolism, 99(10), E2060-E2066.en_US
dc.identifier.issn0021-972X-
dc.identifier.issn1945-7197-
dc.identifier.urihttps://doi.org/10.1210/jc.2014-1641-
dc.identifier.urihttps://academic.oup.com/jcem/article/99/10/E2060/2836233?login=true-
dc.identifier.urihttp://hdl.handle.net/11452/33890-
dc.description.abstractContext: Although patients with acromegaly may have an increased risk of developing several types of cancers, the degree of risk for malignancy in these patients is unresolved. Objective: The present study aimed to investigate the potential genotoxic effects of acromegaly on the cell cycle in peripheral blood lymphocyte cultures. Design: This was a single center, crossover, case-control study conducted on the acromegalic patients in Turkey. Setting: The study was conducted in the outpatient clinic of a university hospital. Patients: Seventy-one consecutively screened acromegalic patients and 56 controls participated in the study. Intervention: Patients were included, regardless of the disease activity status and their treatment duration before the study. Main Outcome Measures: The primary end point was the frequency of micronucleus (MN) in the peripheral blood lymphocyte cultures, and the secondary end point was its clinical correlations. Results: The MN level was 3.82 +/- 1.49 in the control group and 18.00 +/- 6.13 in the acromegalic group (P < .01), whereas the nuclear division index (NDI) was 1.79 +/- 0.12 in the control group and 1.68 +/- 0.07 in the acromegalic group (P < .01). Neither MN nor NDI was correlated with age, GH, IGF-I, initial GH, initial IGF-I, duration of the remission period, and initial tumor size. Only the MN level was positively correlated with the duration of disease (r = 0.323, P = .014). Conclusion: Our results indicated that acromegalic patients had genotoxic damage at a substantial level, and there was a positive correlation between the duration of disease and genotoxicity level.en_US
dc.language.isoenen_US
dc.publisherEndocrine Societyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGrowth-hormone receptoren_US
dc.subjectExposureen_US
dc.subjectDna-damage presenten_US
dc.subjectRisken_US
dc.subjectIn-vitroen_US
dc.subjectFrequencyen_US
dc.subjectOxidative stressen_US
dc.subjectCell-cultureen_US
dc.subjectCancer-patientsen_US
dc.subjectBreast-canceren_US
dc.subjectEndocrinology & metabolismen_US
dc.subject.meshAcromegalyen_US
dc.subject.meshAdulten_US
dc.subject.meshCase-control studiesen_US
dc.subject.meshCells, cultureden_US
dc.subject.meshCross-over studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHuman growth hormoneen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin-like growth factor Ien_US
dc.subject.meshLymphocytesen_US
dc.subject.meshMaleen_US
dc.subject.meshMicronucleus testsen_US
dc.subject.meshMiddle ageden_US
dc.subject.meshMutagenicity testsen_US
dc.subject.meshNeoplasmsen_US
dc.subject.meshRisk factorsen_US
dc.subject.meshTurkeyen_US
dc.titleInvestigation of genotoxicity in acromegaly from peripheral blood lymphocyte cultures using a micronucleus assayen_US
dc.typeArticleen_US
dc.identifier.wos000343423300031tr_TR
dc.identifier.scopus2-s2.0-84907612373tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.tr_TR
dc.contributor.orcid0000-0002-3595-6286tr_TR
dc.contributor.orcid0000-0002-7687-3284tr_TR
dc.identifier.startpageE2060tr_TR
dc.identifier.endpageE2066tr_TR
dc.identifier.volume99tr_TR
dc.identifier.issue10tr_TR
dc.relation.journalJournal of Clinical Endocrinology and Metabolismen_US
dc.contributor.buuauthorÜnal, Oǧuz Kaan-
dc.contributor.buuauthorCinkılıç, Nilüfer-
dc.contributor.buuauthorGül, Özen Öz-
dc.contributor.buuauthorCander, Soner-
dc.contributor.buuauthorVatan, Özgür-
dc.contributor.buuauthorErsoy, Canan Özyardımcı-
dc.contributor.buuauthorYılmaz, Dilek-
dc.contributor.buuauthorTuncel, Ercan-
dc.contributor.researcheridAAI-1005-2021tr_TR
dc.contributor.researcheridAAH-5296-2021tr_TR
dc.contributor.researcheridO-7508-2015tr_TR
dc.contributor.researcheridAAH-8861-2021tr_TR
dc.identifier.pubmed24963647tr_TR
dc.subject.wosEndocrinology & metabolismen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ1en_US
dc.contributor.scopusid55042241400tr_TR
dc.contributor.scopusid26533892300tr_TR
dc.contributor.scopusid26040787100tr_TR
dc.contributor.scopusid25027068600tr_TR
dc.contributor.scopusid16235098100tr_TR
dc.contributor.scopusid6701485882tr_TR
dc.contributor.scopusid6701369462tr_TR
dc.contributor.scopusid7006929833tr_TR
dc.subject.scopusMicronucleus Tests; DNA Damage; Cytokinesisen_US
dc.subject.emtreeAcromegalyen_US
dc.subject.emtreeAdulten_US
dc.subject.emtreeAgeen_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeCell cycleen_US
dc.subject.emtreeCellular parametersen_US
dc.subject.emtreeClinical assessmenten_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeDisease activityen_US
dc.subject.emtreeDisease durationen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeGenotoxicityen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeHuman cell cultureen_US
dc.subject.emtreeLymphocyte cultureen_US
dc.subject.emtreeMajor clinical studyen_US
dc.subject.emtreeMaleen_US
dc.subject.emtreeMethodologyen_US
dc.subject.emtreeMicronucleusen_US
dc.subject.emtreeMicronucleus testen_US
dc.subject.emtreeOutpatient departmenten_US
dc.subject.emtreePeripheral lymphocyteen_US
dc.subject.emtreePopulation based case control studyen_US
dc.subject.emtreeRemissionen_US
dc.subject.emtreeTreatment durationen_US
dc.subject.emtreeTumor volumeen_US
dc.subject.emtreeTurkey (republic)en_US
dc.subject.emtreeUniversity hospitalen_US
dc.subject.emtreeAcromegalyen_US
dc.subject.emtreeCase control studyen_US
dc.subject.emtreeCell cultureen_US
dc.subject.emtreeCrossover procedureen_US
dc.subject.emtreeCytologyen_US
dc.subject.emtreeEpidemiologyen_US
dc.subject.emtreeGeneticsen_US
dc.subject.emtreeLymphocyteen_US
dc.subject.emtreeMiddle ageden_US
dc.subject.emtreeMutagen testingen_US
dc.subject.emtreeNeoplasmsen_US
dc.subject.emtreePhysiologyen_US
dc.subject.emtreeProceduresen_US
dc.subject.emtreeRisk factoren_US
dc.subject.emtreeTurkeyen_US
dc.subject.emtreeGrowth hormoneen_US
dc.subject.emtreeSomatomedin cen_US
dc.subject.emtreeHuman growth hormoneen_US
dc.subject.emtreeSomatomedin cen_US
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