Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/33890
Title: Investigation of genotoxicity in acromegaly from peripheral blood lymphocyte cultures using a micronucleus assay
Authors: Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
0000-0002-3595-6286
0000-0002-7687-3284
Ünal, Oǧuz Kaan
Cinkılıç, Nilüfer
Gül, Özen Öz
Cander, Soner
Vatan, Özgür
Ersoy, Canan Özyardımcı
Yılmaz, Dilek
Tuncel, Ercan
AAI-1005-2021
AAH-5296-2021
O-7508-2015
AAH-8861-2021
55042241400
26533892300
26040787100
25027068600
16235098100
6701485882
6701369462
7006929833
Keywords: Growth-hormone receptor
Exposure
Dna-damage present
Risk
In-vitro
Frequency
Oxidative stress
Cell-culture
Cancer-patients
Breast-cancer
Endocrinology & metabolism
Issue Date: 17-Jul-2014
Publisher: Endocrine Society
Citation: Ünal, O. K. vd. (2014). "Investigation of genotoxicity in acromegaly from peripheral blood lymphocyte cultures using a micronucleus assay". Journal of Clinical Endocrinology and Metabolism, 99(10), E2060-E2066.
Abstract: Context: Although patients with acromegaly may have an increased risk of developing several types of cancers, the degree of risk for malignancy in these patients is unresolved. Objective: The present study aimed to investigate the potential genotoxic effects of acromegaly on the cell cycle in peripheral blood lymphocyte cultures. Design: This was a single center, crossover, case-control study conducted on the acromegalic patients in Turkey. Setting: The study was conducted in the outpatient clinic of a university hospital. Patients: Seventy-one consecutively screened acromegalic patients and 56 controls participated in the study. Intervention: Patients were included, regardless of the disease activity status and their treatment duration before the study. Main Outcome Measures: The primary end point was the frequency of micronucleus (MN) in the peripheral blood lymphocyte cultures, and the secondary end point was its clinical correlations. Results: The MN level was 3.82 +/- 1.49 in the control group and 18.00 +/- 6.13 in the acromegalic group (P < .01), whereas the nuclear division index (NDI) was 1.79 +/- 0.12 in the control group and 1.68 +/- 0.07 in the acromegalic group (P < .01). Neither MN nor NDI was correlated with age, GH, IGF-I, initial GH, initial IGF-I, duration of the remission period, and initial tumor size. Only the MN level was positively correlated with the duration of disease (r = 0.323, P = .014). Conclusion: Our results indicated that acromegalic patients had genotoxic damage at a substantial level, and there was a positive correlation between the duration of disease and genotoxicity level.
URI: https://doi.org/10.1210/jc.2014-1641
https://academic.oup.com/jcem/article/99/10/E2060/2836233?login=true
http://hdl.handle.net/11452/33890
ISSN: 0021-972X
1945-7197
Appears in Collections:Scopus
Web of Science

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