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Başlık: Solid lipid nanoparticles in reversing the acquired tamoxifen-resistance
Yazarlar: Eskiler, Gamze Güney
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
0000-0002-3820-424X
0000-0001-7904-883X
0000-0002-1619-6680
Çeçener, Gülşah
Egeli, Ünal
Tunca, Berrin
AAP-9988-2020
AAH-1420-2021
ABI-6078-2020
6508156530
55665145000
6602965754
Anahtar kelimeler: Computer science
Engineering
Medical informatics
Breast cancer
Tamoxifen
Multi-drug resistance (MDR)
Nanoparticle drug delivery systems
Solid lipid nanoparticles (SLNs)
Of-the-art
Breast-cancer
Drug-delivery
Cell death
Diseases
Drug therapy
Electric resistance
Hydrophobicity
Nanoparticles
Breast cancer
Drug delivery system
Multidrug resistance
Solid lipid nanoparticles
Tamoxifen
Controlled drug delivery
Yayın Tarihi: 2017
Yayıncı: IEEE
Atıf: Eskiler, G. G. vd. (2017). ''Solid lipid nanoparticles in reversing the acquired tamoxifen-resistance''. E-Health and Bioengineering Conference, 2017 IEEE international conference on e-health and bioengineering conference (EHB), 177-180.
Özet: The anti-estrogen tamoxifen (Tam) is the most preferred option for patients with estrogen-receptor (ER)-positive breast cancer. However, multi-drug resistance (MDR) is a considerable clinical problem in the successful chemotherapeutic treatment. Members of the ATP-binding cassette (ABC) transporter family proteins play an important role in acquired drug resistance. Many studies have focused primarily on the clinical significance of P-gp (MDR1), BCRP and MRP1 members belong to ABC transporter superfamily on anticancer-drug resistance. Consequently, several strategies have been improved to overcome drug resistance. Nanoparticle drug delivery systems provide an increase in the intracellular concentration of the drugs as well as a reduction in toxicity of free-drug on healthy cells thanks to unique physical and biological properties. Solid lipid nanoparticles (SLNs) have been improved as an alternative colloidal drug delivery systems due to successful incorporation of both hydrophilic and hydrophobic compounds and their related benefits (controlled drug release, high entrapment efficiency and small size etc.) For this purpose, the aim of this study was to discuss the role of Tam-loaded solid lipid nanoparticles (SLNs) to overcome MDR and determine the ability of Tam-SLNs to induce apoptosis.
Açıklama: Bu çalışma, 22-24 Haziran, 2017 tarihlerinde Sinaia[Romanya]’da düzenlenen 6. IEEE International Conference on E-Health and Bioengineering (EHB) Kongresi‘nde bildiri olarak sunulmuştur.
URI: http://hdl.handle.net/11452/33902
ISBN: 978-1-5386-0358-1
ISSN: 2575-5137
2575-5145
Koleksiyonlarda Görünür:Scopus
Web of Science

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