Bursa Uludağ Üniversitesi Açık Erişim Sistemi
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http://hdl.handle.net/11452/34020| Başlık: | Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method |
| Yazarlar: | Yılmaz, Begümhan Doğan, Serap Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü. Kasımoğulları, Serap Çelik 8234554800 |
| Anahtar kelimeler: | Materials science, biomaterials Polymer science Cytotoxicity Genotoxicity Hemocompatibility Nanocomposite Nanohydroxyapatite PMMA Electrophoresis comet assay DNA-damage In-vitro Human-lymphocytes Individual cells Resin monomers Composite Cement Tissue Bone Biocompatibility Blending Esters Nanocomposites Phosphatases Cytotoxic effects Genotoxicities Human lymphocytes Melt-blending methods Poly(methyl methacrylate) (PMMA) |
| Yayın Tarihi: | 2018 |
| Yayıncı: | Taylor & Francis |
| Atıf: | Yılmaz, B. vd. (2018). ''Hemocompatibility, cytotoxicity, and genotoxicity of poly(methylmethacrylate)/nanohydroxyapatite nanocomposites synthesized by melt blending method''. International Journal of Polymeric Materials and Polymeric Biomaterials, 67(6), 351-360. |
| Özet: | The aim of this study was to show the hemocompatibility, cytotoxicity, and genotoxicity of nanocomposites that were synthesized with different molecular weights of poly(methyl methacrylate) (PMMA) and different concentrations of nanohydroxyapatite (nHAp). Different techniques to characterize the nanocomposites were used. The cytotoxicity and genotoxic effects of the polymers and nanocomposites on human lymphocytes were determined by acid phosphatase assay, viability test, and comet assay. Moreover, hemocompatibility test was performed. It was found that all of the PMMA/nHAp nanocomposites are highly hemocompatible and biocompatible, none of the nanocomposites showed a cytotoxic effect, and nHAp addition decreased the genotoxicity. |
| URI: | https://doi.org/10.1080/00914037.2017.1331349 https://www.tandfonline.com/doi/full/10.1080/00914037.2017.1331349 http://hdl.handle.net/11452/34020 |
| ISSN: | 0091-4037 1563-535X |
| Koleksiyonlarda Görünür: | Scopus Web of Science |
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