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Başlık: Promising anticancer activity of a lichen, Parmelia sulcata Taylor, against breast cancer cell lines and genotoxic effect on human lymphocytes
Yazarlar: Özel, Mustafa Zafer
Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.
Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Kimya Bölümü.
0000-0002-6729-7908
0000-0003-4875-5472
0000-0001-8196-2065
0000-0002-4177-3478
0000-0002-1284-7992
Arı, Ferda
Ulukaya, Engin
Oran, Seyhan
Celikler, Serap
Ozturk, Sule
AAG-7012-2021
K-5792-2018
AAH-5039-2021
AAH-2767-2021
AAD-7322-2019
24376085300
6602927353
14067648200
8234554800
7004555373
Anahtar kelimeler: Parmelia sulcata
Cell death
Apoptosis
Breast cancer
Treatment
DNA damage
In-vitro
Cytotoxic activities
Antioxidant
Metabolites
Extracts
Assay
Murine
Biotechnology & applied microbiology
Cell biology
Yayın Tarihi: 1-May-2015
Yayıncı: Springer
Atıf: Arı, F. vd. (2015). "Promising anticancer activity of a lichen, Parmelia sulcata Taylor, against breast cancer cell lines and genotoxic effect on human lymphocytes". Cytotechnology, 67(3), 531-543.
Özet: Plants are still to be explored for new anticancer compounds because overall success in cancer treatment is still not satisfactory. As a new possible source for such compounds, the lichens are recently taking a great attention. We, therefore, explored both the genotoxic and anti-growth properties of lichen species Parmelia sulcata Taylor. The chemical composition of P. sulcata was analyzed with comprehensive gas chromatography-time of flight mass spectrometry. Anti-growth effect was tested in human breast cancer cell lines (MCF-7 and MDA-MB-231) by the MTT and ATP viability assays, while the genotoxic activity was studied by assays for micronucleus, chromosomal aberration and DNA fragmentation in human lymphocytes culture. Cell death modes (apoptosis/necrosis) were morphologically assessed. P. sulcata inhibited the growth in a dose-dependent manner up to a dose of 100 mu g/ml and induced caspase-independent apoptosis. It also showed genotoxic activity at doses (>125 mu g/ml) higher than that required for apoptosis. These results suggest that P. sulcata may induce caspase-independent apoptotic cell death at lower doses, while it may be genotoxic at relatively higher doses.
URI: https://doi.org/10.1007/s10616-014-9713-4
https://link.springer.com/article/10.1007/s10616-014-9713-4
http://hdl.handle.net/11452/34190
ISSN: 0920-9069
Koleksiyonlarda Görünür:Scopus
Web of Science

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