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Başlık: Impact of 3'UTR variation patterns of the KRAS gene on the aggressiveness of pancreatobiliary tumors with the KRAS G13D mutation in a Turkish population
Yazarlar: Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.
Uludağ Üniversitesi/Tıp Fakültes/ Patoloji Anabilim Dalı.
0000-0002-5956-8755
0000-0002-9732-5340
0000-0002-3760-9755
0000-0002-1619-6680
0000-0002-3820-424X
0000-0002-9562-4195
0000-0001-7904-883X
Egeli, Ünal
Ak, Seçil
Çeçener, Gülşah
Tunca, Berrin
Tezcan, Gülçin
Sevinç, Elif Demirdoğen
Kaya, Ekrem
Dündar, Halit Ziya
Sarkut, Pınar
Özen, Yılmaz
Balçin, Özkan
Evrensel, Türkkan
Yerci, Ömer
Uğraş, Nesrin
AAH-3843-2020
AAJ-1027-2021
AAH-2716-2021
F-8554-2017
ADM-8457-2022
ABI-6078-2020
AAP-9988-2020
AAG-7319-2021
AAH-1420-2021
IOO-2699-2023
EWI-3634-2022
HKB-5363-2023
FOQ-1792-2022
AHB-4845-2022
EGD-8703-2022
55665145000
55253485700
6508156530
6602965754
25650627600
56508326500
7004568109
55453773300
55806454400
6508243334
57189756976
6603942124
6603810549
55386535600
Anahtar kelimeler: Gastroenterology & hepatology
KRAS
3' untranslated region
Codon 13
Mutation
Invasion
K-ras gene
Cancer
Pancreas
Codon-12
Polymorphism
Expression
Carcinoma
p53
Adenocarcinoma
Micrornas
Yayın Tarihi: 20-May-2016
Yayıncı: Elsevier
Atıf: Egeli, Ü. vd. (2016). "Impact of 3'UTR variation patterns of the KRAS gene on the aggressiveness of pancreatobiliary tumors with the KRAS G13D mutation in a Turkish population". Pancreatology, 16(4), 677-686.
Özet: Objective: Several studies have demonstrated the importance of mutations in codons 12, 13 and 61 and variations in the 3' untranslated region (3'UTR) of the ICRAS gene, frequently observed genetic events in the progression of pancreatobiliary tumors (PBT). However, limited data exist on the clinical effect of these alterations. The aim of the current study was to clarify the frequency of relevant alterations of the 3'UTR regions of the KRAS gene and the effect of KRAS 3'UTR polymorphisms on the prognosis of patients with codon 12, 13 and 61 mutations in a Turkish population with PBT.Methods: Codons 12, 13, and 61 and 3'UTRs of the KRAS gene were screened by single-strand conformation polymorphism (SSCP) analysis and DNA sequencing in 43 patients and 10 controls. Chi-squared and independent sample T tests were used to evaluate the results of the mutation analysis and clinical features of the patients.Results: We defined the c.38G > A (rs112445441, p.G13D) (39.54%) mutation and two 3'UTR variations, c.*4066delA (rs560890523) (23.26%) and c.*406524066delAA (rs57698689) (6.98%), in the ICRAS gene of Turkish patients. There was a statistically significant relationship between the c.*4066delA (rs560890523) and c.*406524066delAA (rs57698689) variations and invasion and lymph node metastasis status of the patients (p < 0.001). Compared to patients with c.38G > A (rs112445441, p.G13D), patients with c.*4066delA (rs560890523) and c.38G > A (rs112445441, p.G13D) presented more aggressive tumors with highly invasive features. The present study contributes findings regarding the clinical effects of KRAS alterations in PBT. Based on our study, further investigations are required.
URI: https://doi.org/10.1016/j.pan.2016.05.004
https://www.sciencedirect.com/science/article/pii/S1424390316300722
http://hdl.handle.net/11452/34306
ISSN: 1424-3903
1424-3911
Koleksiyonlarda Görünür:Scopus
Web of Science

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