Please use this identifier to cite or link to this item:
http://hdl.handle.net/11452/34480
Title: | Alterations of serum cytokine levels and their relation with inflammatory markers in candidemia |
Authors: | Gürcüoğlu, Emel Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı. Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı. 0000-0001-7625-9148 0000-0002-4803-8206 0000-0003-0463-6818 Akın, Hicran Akalın, Halis Budak, Ferah Ener, Beyza Ocakoğlu, Gökhan Göral, Güher Oral, Haluk Barbaros CBT-0656-2022 AAU-8952-2020 F-4657-2014 AAG-8523-2021 AAH-5180-2021 EUR-5589-2022 K-7285-2012 54782139900 57207553671 6701913697 15053025300 15832295800 6603453166 7004498001 |
Keywords: | Infectious diseases Mycology Veterinary sciences Candidemia IL-17 IL-23 PCT Sepsis C-reactive protein Critically-ill patients Necrosis-factor-alpha Intensive-care-unit Invasive candidiasis International multicenter Procalcitonin PCT Response syndrome Early-diagnosis Severe sepsis |
Issue Date: | 1-Apr-2015 |
Publisher: | Oxford University |
Citation: | Akın, H. vd. (2015). "Alterations of serum cytokine levels and their relation with inflammatory markers in candidemia". Medical Mycology, 53(3), 258-268. |
Abstract: | The roles of CRP, PCT, serum amyloid A (SAA), and cytokines in the diagnosis of fungal infections have not yet been clearly demonstrated. This study aims to measure the serum levels of interleukin (IL)-23, IL-17, IL-1 beta, tumor necrosis factor (TNF)-alpha, IL-10, transforming growth factor (TGF)-beta, C-reactive protein (CRP), procalcitonin (PCT), and serum amyloid A (SAA) in cases of candidemia and to compare them with those observed in cases of bacteremia. For this purpose, the serum cytokine levels from 50 patients with candidemia were compared with those of 14 patients with polymicrobial sepsis, 30 patients with bacteremia, and 27 healthy control subjects. The cytokine levels were studied using sandwich ELISAs according to the manufacturer protocol. The serum levels of TGF-beta, IL-23, and IL-17 were found to be significantly higher in the candidemia group in comparison with the samples from those with bacteremia and healthy controls. The PCT and SAA levels were higher in samples from the group with bacteremia those from individuals with candidemia and the healthy control group. Assuming an IL-17 level threshold of > 38.79 pg/ml, the sensitivity and specificity were 38% and 96.6%, respectively but considering an IL-23 threshold of > 59.97 pg/ml, the sensitivity and specificity valueswere found to be 72% and 60%, respectively. The sensitivity and the specificity of the TGF-beta levels were found to be 85.71% and 53.33%, respectively, when the TGF-beta threshold is > 560 pg/ml. PCT and SAA demonstrated a superior performance for the differentiation of candidemia and bacteremia. Our study demonstrates that IL-17, IL-23, TGF-beta, PCT, and SAA levels could be a diagnostic marker for candidemia |
URI: | https://doi.org/10.1093/mmy/myu084 https://academic.oup.com/mmy/article/53/3/258/2579529 http://hdl.handle.net/11452/34480 |
ISSN: | 1369-3786 |
Appears in Collections: | Scopus Web of Science |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Akın_vd_2015.pdf | 1.06 MB | Adobe PDF | ![]() View/Open |
This item is licensed under a Creative Commons License