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Başlık: Hepatoprotective and antioxidant effects of lycopene in acute cholestasis
Yazarlar: Tokaç, Mehmet
Aydın, Sevtap
Taner, Gökçe
Özkardeş, Alper Bilal
Taşlıpınar, Mine Yavuz
Doğan, Mehmet
Kılıç, Mehmet
Başaran, Arif Mehmet
Başaran, Ayşe Nurşen
Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.
0000-0002-7346-7440
Dündar, Halit Ziya
EWI-3634-2022
55453773300
Anahtar kelimeler: General & internal medicine
Lycopene
Cholestasis
DNA damage
Oxidative stress
Peripheral lymphocytes
Liver
Renal oxidative stress
Bile-duct ligation
DNA-damage
Obstructive-jaundice
Hepatic-injury
Liver
Rats
Lymphocytes
Mechanisms
Melatonin
Yayın Tarihi: 27-Haz-2015
Yayıncı: TÜBİTAK
Atıf: Tokaç, M. vd. (2015). "Hepatoprotective and antioxidant effects of lycopene in acute cholestasis". Turkish Journal of Medical Sciences, 45(4), 857-864.
Özet: Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats. Materials and methods: The animals were randomized into 3 groups. The sham group was subjected to a sham operation, the BDL group was subjected to bile duct ligation (BDL), and the BDL+L group was subjected to BDL and treated with 10 mg/kg body weight of lycopene. After 7 days of treatment, the liver functions, oxidative stress parameters, and DNA damage were evaluated. Results: The lycopene treatment significantly ameliorated the liver function parameters in BDL rats. It significantly reduced malondialdehyde and nitric oxide levels and enhanced reduced glutathione levels and catalase, superoxide dismutase, and glutathione S transferase activities in the BDL rats. The lycopene treatment also decreased DNA damage as assessed by comet assay in the lymphocytes and hepatocytes of the BDL rats. Conclusion: These results suggest that lycopene might have protective effects on acute cholestasis.
URI: https://doi.org/10.3906/sag-1404-57
https://journals.tubitak.gov.tr/medical/vol45/iss4/19/
http://hdl.handle.net/11452/34531
ISSN: 1300-0144
Koleksiyonlarda Görünür:Scopus
TrDizin
Web of Science

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