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Başlık: Effects of intracerebroventricularly injected glucagon-like peptide-2 on ethanol-induced gastric mucosal damage in rats
Yazarlar: Suyen, Güldal Güleç
Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.
İşbil, Naciye Büyükcoşkun
Cam, Betül
Özlük, Kasım
AAH-1692-2021
55665951400
56427863700
6602676331
Anahtar kelimeler: Endocrinology & metabolism
Ethanol
Gastric mucosal damage
Glucagon-like peptide-2
I.C.V.
Rat
Gene-related peptide
Blood-flownitric-oxide
Enteric neurons
Glp-2 receptor
Neuropeptides
Protection
Injury
Immunoreactivity
Prostaglandins
Yayın Tarihi: 29-Mar-2018
Yayıncı: Taylor & Francis
Atıf: İşbil, B. N. vd. (2018). ''Effects of intracerebroventricularly injected glucagon-like peptide-2 on ethanol-induced gastric mucosal damage in rats''. Endocrine Research, 43(4), 220-227.
Özet: Purpose: The present study aims to investigate the effects of intracerebroventricularly (i.c.v.)-injected glucagon-like peptide-2 (GLP-2) on ethanol-induced gastric mucosal damage and to reveal the mechanisms involved in this effect. Materials and Methods: Rats received absolute ethanol orally via an orogastric tube 30minutes after GLP-2 (1-200 ng/10 mu l; i.c.v.) or saline (10 mu l) injections. They were decapitated 1 hour later, their stomachs were removed, and the gastric mucosal damage was scored. Results: A total of 100 ng GLP-2 inhibited the gastric mucosal damage by 67%. This effect was abolished by the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP-(8-37) (10 mu g/kg; s.c.), but was not affected by either the nitric oxide (NO) synthase inhibitor L-NAME (30 mg/kg; s.c.) or the cyclooxygenase inhibitor indomethacin (5 mg/kg; i.p.). The most effective gastroprotective dose of GLP-2 (100 ng/10 mu l; i.c.v.), but not the higher doses (150 or 200 ng/10 mu l; i.c.v.) prevented the decrease in gastric mucosal blood flow caused by ethanol. In conclusion, i.c.v. GLP-2 protects against ethanol-induced gastric mucosal damage and this effect is mediated by CGRP receptor activation and gastric mucosal blood flow, but not by NO or prostaglandins.
URI: https://doi.org/10.1080/07435800.2018.1460604
https://www.tandfonline.com/doi/full/10.1080/07435800.2018.1460604
http://hdl.handle.net/11452/34822
ISSN: 0743-5800
1532-4206
Koleksiyonlarda Görünür:Scopus
Web of Science

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