Please use this identifier to cite or link to this item: http://hdl.handle.net/11452/34939
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dc.contributor.authorGüvenç, Furkan-
dc.date.accessioned2023-11-17T12:00:14Z-
dc.date.available2023-11-17T12:00:14Z-
dc.date.issued2018-
dc.identifier.citationBal, S. H. vd. (2018). ''Effect of storage period of red blood cell suspensions on helper T-cell subpopulations''. Blood Transfusion, 16(3), 262-272.en_US
dc.identifier.issn1723-2007-
dc.identifier.urihttps://doi.org/10.2450/2017.0238-16-
dc.identifier.urihttps://www.bloodtransfusion.it/bt/article/view/323-
dc.identifier.urihttp://hdl.handle.net/11452/34939-
dc.description.abstractBackground. The aim of this study was to investigate the immunological alterations that occur during the storage of erythrocyte suspensions which may lead to transfusion-related immunomodulation following allogeneic blood transfusion. Materials and methods. One part of the erythrocyte suspensions obtained from donors was leucoreduced while the other part was not. The leucoreduced (LR) and non-leucoreduced (NL) erythrocyte suspensions were then further divided into three equal amounts which were stored for 0, 21 or 42 days prior to measurements, by enzyme-linked immunosorbent assays, of cytokine levels in their supernatants. T-helper (Th) lymphocyte subgroups and gene expression were analysed in the NL erythrocyte suspensions by flow cytometry and real-time polymerase chain reaction, respectively. Results were compared to those of storage day 0. Results. By day 21, the number of Th2 cells had increased significantly and the numbers of Th1, Th22 and Treg cells had decreased significantly in the NL erythrocyte suspensions. On day 42 the numbers of Th2 and Treg cells in the NL suspensions were significantly increased while the number of Th1 cells was significantly decreased. The levels of transcription factors (TBX21, GATA3, and SPI.1) were significantly decreased on days 21 and 42, and AHR, FOXP3 and RORC2 levels were significantly increased on day 42 in NL erythrocyte suspensions. The decrease in interleukin-22 and increase in transforming growth factor-beta levels found in NL erythrocyte suspensions on day 21 were statistically significant. Elevated levels of interleukin-17A were found in both LR and NL erythrocyte suspensions on day 42. Discussion. Our results suggest that allogeneic leucocytes and cytokines may play significant roles in the development of transfusion-related immunomodulation.en_US
dc.language.isoenen_US
dc.publisherSimtipro Srlen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHematologyen_US
dc.subjectTRIMen_US
dc.subjectImmunomodulationen_US
dc.subjectTransfusionen_US
dc.subjectTh cell subgroupsen_US
dc.subjectLeucoreductionen_US
dc.subjectRandomized controlled-trialen_US
dc.subjectTransfusion-related immunomodulationen_US
dc.subjectColorectal-cancer surgeryen_US
dc.subjectIndependent risk-factoren_US
dc.subjectGrowth-factor-betaen_US
dc.subjectAcute lung injuryen_US
dc.subjectCardiac-surgeryen_US
dc.subjectWhole-blooden_US
dc.subjectPostoperative infectionen_US
dc.subjectLeukocyte depletionen_US
dc.subject.meshAntigens, differentiationen_US
dc.subject.meshBlood preservationen_US
dc.subject.meshErythrocytesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukinsen_US
dc.subject.meshMaleen_US
dc.subject.meshT-Lymphocytes, helper-induceren_US
dc.titleEffect of storage period of red blood cell suspensions on helper T-cell subpopulationsen_US
dc.typeArticleen_US
dc.identifier.wos000430721500007tr_TR
dc.identifier.scopus2-s2.0-85046155053tr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergitr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Dr. Raşit Durusoy Kan Bankası.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Mikrobiyoloji/İmmünoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.tr_TR
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.tr_TR
dc.relation.bapUAP[T]-2011/53tr_TR
dc.contributor.orcid0000-0001-7625-9148tr_TR
dc.contributor.orcid0000-0003-0463-6818tr_TR
dc.identifier.startpage262tr_TR
dc.identifier.endpage272tr_TR
dc.identifier.volume16tr_TR
dc.identifier.issue3tr_TR
dc.relation.journalBlood Transfusionen_US
dc.contributor.buuauthorBal, Salih Haldun-
dc.contributor.buuauthorKumaş, Levent Tufan-
dc.contributor.buuauthorBudak, Ferah-
dc.contributor.buuauthorGöral, Güher-
dc.contributor.buuauthorOral, Haluk Barbaros-
dc.contributor.buuauthorHeper, Yasemin-
dc.contributor.researcheridHJY-9001-2023tr_TR
dc.contributor.researcheridF-4657-2014tr_TR
dc.contributor.researcheridAAH-6506-2021tr_TR
dc.contributor.researcheridK-7285-2012tr_TR
dc.relation.collaborationYurt dışıtr_TR
dc.identifier.pubmed28488961tr_TR
dc.subject.wosHematologyen_US
dc.indexed.wosSCIEen_US
dc.indexed.scopusScopusen_US
dc.indexed.pubmedPubMeden_US
dc.wos.quartileQ2en_US
dc.contributor.scopusid56191003300tr_TR
dc.contributor.scopusid26665534000tr_TR
dc.contributor.scopusid6701913697tr_TR
dc.contributor.scopusid6603453166tr_TR
dc.contributor.scopusid7004498001tr_TR
dc.contributor.scopusid57191480128tr_TR
dc.subject.scopusBlood Transfusion; Cystectomy; Outcomeen_US
dc.subject.emtreeAhr proteinen_US
dc.subject.emtreeInterleukin 17en_US
dc.subject.emtreeInterleukin 22en_US
dc.subject.emtreeProteinen_US
dc.subject.emtreeRorc2 proteinen_US
dc.subject.emtreeTranscription factor FOXP3en_US
dc.subject.emtreeTranscription factor GATA 3en_US
dc.subject.emtreeTranscription factor Sp1en_US
dc.subject.emtreeTranscription factor T beten_US
dc.subject.emtreeTransforming growth factor betaen_US
dc.subject.emtreeUnclassified drugen_US
dc.subject.emtreeDifferentiation antigenen_US
dc.subject.emtreeInterleukin derivativeen_US
dc.subject.emtreeInterleukin-22en_US
dc.subject.emtreeArticleen_US
dc.subject.emtreeBlood donoren_US
dc.subject.emtreeBlood storageen_US
dc.subject.emtreeCell suspensionen_US
dc.subject.emtreeControlled studyen_US
dc.subject.emtreeEnzyme linked immunosorbent assayen_US
dc.subject.emtreeErythrocyte transfusionen_US
dc.subject.emtreeFlow cytometryen_US
dc.subject.emtreeGene expressionen_US
dc.subject.emtreeHumanen_US
dc.subject.emtreeHuman cellen_US
dc.subject.emtreeImmunomodulationen_US
dc.subject.emtreeReal time polymerase chain reactionen_US
dc.subject.emtreeRegulatory T lymphocyteen_US
dc.subject.emtreeSupernatanten_US
dc.subject.emtreeT lymphocyte subpopulationen_US
dc.subject.emtreeTh2 cellen_US
dc.subject.emtreeTh22 cellen_US
dc.subject.emtreeCytologyen_US
dc.subject.emtreeErythrocyteen_US
dc.subject.emtreeFemaleen_US
dc.subject.emtreeHelper cellen_US
dc.subject.emtreeImmunologyen_US
dc.subject.emtreeMaleen_US
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